Genes in panel
STRs in panel
Prev Next

COVID-19 research

Gene: HAVCR1

Green List (high evidence)

HAVCR1 (hepatitis A virus cellular receptor 1)
EnsemblGeneIds (GRCh38): ENSG00000113249
EnsemblGeneIds (GRCh37): ENSG00000113249
OMIM: 606518, Gene2Phenotype
HAVCR1 is in 1 panel

2 reviews

Alison Coffey (Illumina Clinical Services Laboratory, Illumina Inc.)

Green List (high evidence)

Evidence Summary from Illumina curation team: HAVCR1 encodes the human hepatitis A virus (HAV) cellular receptor 1 (CD365, TIM1, KIM1) a phospholipid receptor which is expressed in mucosal epthelium from a range of tissues including trachea, conjunctiva and cornea (Kondratowicz et al. 2011). HAVCR1 acts as a cell receptor or entry factor for a number of enveloped viruses including Hepatitis A, Ebolavirus, Marberg virus and Dengue virus (Kondratowicz et al. 2011; Costfreda et al. 2018; Meertens et al. 2012).
Created: 28 May 2020, 3:12 p.m. | Last Modified: 28 May 2020, 3:12 p.m.
Panel Version: 0.347

Publications

Rebecca Foulger (Genomics England curator)

Identified through an OMIM search for potential viral susceptibility genes, and subsequently triaged/reviewed by Illumina curation team.
Created: 28 May 2020, 2:05 p.m. | Last Modified: 28 May 2020, 2:05 p.m.
Panel Version: 0.339

Details

Mode of Inheritance
Unknown
Sources
OMIM
606518
Clinvar variants
Variants in HAVCR1
Penetrance
None
Publications
Panels with this gene

History Filter Activity

28 May 2020, Gel status: 3

Created, Added New Source, Set mode of inheritance, Set publications

Rebecca Foulger (Genomics England curator)

gene: HAVCR1 was added gene: HAVCR1 was added to COVID-19 research. Sources: Expert list,OMIM,Expert Review Green Mode of inheritance for gene: HAVCR1 was set to Unknown Publications for gene: HAVCR1 were set to 29321304; 21536871; 23084921; 29437974; 9658108