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COVID-19 research

Gene: SPNS3

Red List (low evidence)

SPNS3 (sphingolipid transporter 3 (putative))
EnsemblGeneIds (GRCh38): ENSG00000182557
EnsemblGeneIds (GRCh37): ENSG00000182557
OMIM: 611701, Gene2Phenotype
SPNS3 is in 1 panel

1 review

Sarah Leigh (Genomics England Curator)

Red List (low evidence)

Using Collaborative Cross mouse genetic reference population, PMID 32348764 studied the genetic regulation of variation in antibody response to influenza A virus (IAV) infection. This enabled the identification of 23 quantitative trait loci (QTL) associated with variation in specific antibody isotypes across time points; this allowed a subset to be found that broadly affect the antibody response to IAV as well as other viruses. This gene is the equivalent human for the mouse gene that was classified as a candidate from one of the QTLs, based on the predicted variant consequences and haplotype-specific expression patterns (PMID 32348764 table 2).
Created: 27 May 2020, 10:50 a.m. | Last Modified: 27 May 2020, 10:50 a.m.
Panel Version: 0.332

Mode of inheritance

Influenza A Virus-Specific Antibody Responses



  • Literature
Clinvar variants
Variants in SPNS3
Panels with this gene

History Filter Activity

5 May 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance

Sarah Leigh (Genomics England Curator)

gene: SPNS3 was added gene: SPNS3 was added to Viral susceptibility. Sources: Literature Mode of inheritance for gene: SPNS3 was set to