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COVID-19 research

Gene: TRIB3

Red List (low evidence)

TRIB3 (tribbles pseudokinase 3)
EnsemblGeneIds (GRCh38): ENSG00000101255
EnsemblGeneIds (GRCh37): ENSG00000101255
OMIM: 607898, Gene2Phenotype
TRIB3 is in 1 panel

1 review

Eleanor Williams (Genomics England Curator)

Preprint - - de Moraes et al
Analyzed Genotype-Tissue Expression (GTEx) data to test whether lung aging is associated with transcriptional changes in human protein-coding genes that potentially interact with these viruses. Identified TRIB3 expression was decreased in older males. Found TRIB3
expressed mainly in alveolar epithelial cells that express SARS-CoV-2 receptor ACE2.

PMID: 27252525 - Tran et al 2016- Silencing of TRIB3 resulted in increased RNA and protein levels of HCV, whereas overexpression of TRIB3 decreased Hepatitis C viral replication
Sources: Literature
Created: 23 Apr 2020, 3:48 a.m.

Mode of inheritance


  • 27252525


Mode of Inheritance
  • Literature
Clinvar variants
Variants in TRIB3
  • 27252525
Panels with this gene

History Filter Activity

23 Apr 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications

Eleanor Williams (Genomics England Curator)

gene: TRIB3 was added gene: TRIB3 was added to Viral susceptibility. Sources: Literature Mode of inheritance for gene: TRIB3 was set to Unknown Publications for gene: TRIB3 were set to 27252525;