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COVID-19 research

Gene: BRF2

Red List (low evidence)

BRF2 (BRF2, RNA polymerase III transcription initiation factor subunit)
EnsemblGeneIds (GRCh38): ENSG00000104221
EnsemblGeneIds (GRCh37): ENSG00000104221
OMIM: 607013, Gene2Phenotype
BRF2 is in 1 panel

1 review

Arina Puzriakova (Genomics England Curator)

Using UK Biobank data of 5,871 participants tested for COVID-19, including 193 deaths from 1,412 confirmed infections, authors identified 5 novel risk variants in 4 genes (ERAP2, BRF2, TMEM181, ALOXE3) associated with death from SARS-CoV-2 infection.

Structural analysis showed the BRF2 SNP (rs138763430, D9N) at the Zn Ribbon domain alters the electrostatic potential surface, which in turn impacts the fundamental property of the domain to recognise nucleotide binding partners. Thus authors speculate that this variant most likely negatively alters the selectivity of the protein. However, whether this genetic variant has any physiological role on SARS-CoV-2 infection is yet to be determined.
Sources: Literature
Created: 29 Jul 2020, 1:05 p.m.

Mode of inheritance


Mode of Inheritance
  • Literature
Clinvar variants
Variants in BRF2
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29 Jul 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance

Arina Puzriakova (Genomics England Curator)

gene: BRF2 was added gene: BRF2 was added to COVID-19 research. Sources: Literature Mode of inheritance for gene: BRF2 was set to Unknown