COVID-19 researchGene: IGKC
No evidence that this leads to clinical immunodeficiency
Created: 20 Jun 2018, 7:10 p.m.
OriginaI Metadata from IUIS classification table (February, 2018) downloaded 20180614. IUIS Genetic defect (original gene symbol in IUIS download): IGKC .PanelApp HGNC gene symbol check: IGKC . IUIS Disease: Kappa chain deficiency . IUIS Inheritance: AR .T cells: Very low, .B cells: N/A, .IUIS Other affected cells: N/A. IUIS Associated features: Asymptomatic. IUIS Major category: Predominantly Antibody Deficiencies. IUIS Subcategory: Isotype, Light Chain, or Functional Deficiencies with Generally Normal Numbers of B Cells
Created: 2 Jul 2018, 10:35 a.m.
After internal and external review it was decided to leave this gene as Amber until more info on gene and disease association. This gene is on the GRID panel.
Created: 21 Jun 2018, 1:10 p.m.
This gene was absent from the original PanelApp PID panel dataset (review April 2018). However it was listed in external expert immunodeficiency diagnostic gene list(s) GOSH or GRID. In this combined PID panel, this gene has been rated as AMBER and needs further curational review to assess pertinence prior to v1.
Created: 20 Apr 2018, 12:25 p.m.
Original metadata downloaded from ESID Registry. ESID_Gene_original: Kappa light chain, PanelApp HGNC gene symbol check: IGKC, ESID classification: Main_category/ Sub_category/ PID_Diagnosis Predominantly antibody disorders / Hypogammaglobulinemias / Immunoglobulin chain deficiencies
Created: 17 Apr 2018, 12:29 p.m.
Original metadata supplied by GRID. GRID Gene Symbol HGNC PanelApp check: IGKC, GRID_Gene_Symbol: IGKC, GRID_Transcript_ENS_Community submitted: ENST00000390237, GRID_Transcript_RefSeq: null, GRID_Transcript_ENS_used_on_Production: ENST00000390237
Created: 17 Apr 2018, 12:12 p.m.
Source Expert Review Green was added to IGKC. Added phenotypes Immunoglobulin chain deficiencies; Kappa light chain deficiency, 614102; Asymptomatic; Predominantly Antibody Deficiencies for gene: IGKC Rating Changed from Amber List (moderate evidence) to Green List (high evidence)
gene: IGKC was added gene: IGKC was added to Viral susceptibility. Sources: ESID Registry 20171117,GRID V2.0,IUIS Classification December 2019,IUIS Classification February 2018,Expert Review Amber Mode of inheritance for gene: IGKC was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: IGKC were set to 32086639; 32048120; 4185453 Phenotypes for gene: IGKC were set to Immunoglobulin chain deficiencies; Kappa light chain deficiency, 614102; Asymptomatic; Predominantly Antibody Deficiencies