COVID-19 research
Gene: IL6
Given importance of IL6 to severe COVID pathogenesis I think it makes sense to consider variants within it, including eQTLs that affect its expression (implies importance of including regulatory regions within targeted virtual panel)Created: 7 May 2020, 4:20 p.m. | Last Modified: 7 May 2020, 4:20 p.m.
Panel Version: 0.204
Preprint https://doi.org/10.1101/2020.05.02.20084673 reports 10 terminally-ill, critical COVID-19 patients with profound elevation of plasma IL-6 and CCL5 (RANTES), decreased CD8+ T cell levels, and SARS-CoV-2 plasma viremia. Treatment with CCR5 blocking antibody leronlimab, results in complete CCR5 receptor occupancy on macrophage and T cells, rapid reduction of plasma IL-6, restoration of the CD4/CD8 ratio, and a significant decrease in SARS-CoV-2 plasma viremia. From single-cell RNA-sequencing, this effect appears to be a result of reduced transcriptomic myeloid cell clusters expressing IL-6 and interferon-related genes.Created: 11 May 2020, 3:18 p.m. | Last Modified: 11 May 2020, 3:18 p.m.
Panel Version: 0.204
Strong association was observed between an IL6 promoter polymorphism (G-174C) and susceptibility to Kaposi Sarcoma (KS) in HIV-infected men (P?=?.0035). Homozygotes for IL6 allele G, associated with increased IL6 production, were over represented among patients with KS (P?=?.0046), whereas allele C homozygotes were under represented (P?=?.0062)(PMID 11001912).Created: 4 May 2020, 3:17 p.m. | Last Modified: 5 May 2020, 8:14 a.m.
Panel Version: 0.179
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Phenotypes
{Kaposi sarcoma, susceptibility to} 148000
Publications
Phenotypes for gene: IL6 were changed from to {Kaposi sarcoma, susceptibility to} 148000
Publications for gene: IL6 were set to
Mode of inheritance for gene: IL6 was changed from to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Gene: il6 has been classified as Green List (High Evidence).
Gene: il6 has been classified as Amber List (Moderate Evidence).
gene: IL6 was added gene: IL6 was added to Viral susceptibility. Sources: OMIM Mode of inheritance for gene: IL6 was set to