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COVID-19 research

Gene: FPR3

Red List (low evidence)

FPR3 (formyl peptide receptor 3)
EnsemblGeneIds (GRCh38): ENSG00000187474
EnsemblGeneIds (GRCh37): ENSG00000187474
OMIM: 136539, Gene2Phenotype
FPR3 is in 2 panels

3 reviews

Catherine Snow (Genomics England)

Red List (low evidence)

Formyl peptide receptors (FPRs) are classical chemoattractant receptors and although FPR3 was recently identified as being expressed in a sepsis patient derived neutrophils (PMID: 31982133) there is not enough evidence to upgrade to Amber.
Created: 8 Apr 2020, 2:51 p.m. | Last Modified: 8 Apr 2020, 2:51 p.m.
Panel Version: 0.74

Sophie Hambleton (Newcastle University)

Red List (low evidence)

No evident link to immunodeficiency
Created: 11 Jun 2018, 2:22 p.m.

Louise Daugherty (Genomics England Curator)

I don't know

External expert review notes Red status due to no evident link to immunodeficiency, so I have kept this gene Red on this panel
Created: 12 Jun 2018, 3:05 p.m.
Original metadata downloaded from ESID Registry. ESID_Gene_original: Formyl peptide receptor, PanelApp HGNC gene symbol check: FPR3, ESID classification: Main_category/ Sub_category/ PID_Diagnosis Phagocytic disorders / Localized juvenile peridontitis / Localized juvenile peridontitis
Created: 17 Apr 2018, 12:29 p.m.


Mode of Inheritance
  • ESID Registry 20171117
  • Expert Review Red
  • Expert Review Red
  • ESID Registry 20171117
  • Localized juvenile peridontitis
Clinvar variants
Variants in FPR3
Panels with this gene

History Filter Activity

1 Apr 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Ellen McDonagh (Genomics England Curator)

gene: FPR3 was added gene: FPR3 was added to Viral susceptibility. Sources: Expert Review Red,ESID Registry 20171117 Mode of inheritance for gene: FPR3 was set to Unknown Phenotypes for gene: FPR3 were set to Localized juvenile peridontitis