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COVID-19 research

Gene: HMOX1

Green List (high evidence)

HMOX1 (heme oxygenase 1)
EnsemblGeneIds (GRCh38): ENSG00000100292
EnsemblGeneIds (GRCh37): ENSG00000100292
OMIM: 141250, Gene2Phenotype
HMOX1 is in 2 panels

2 reviews

Louise Daugherty (Genomics England Curator)

Comment on publications: Added publications suggested from external expert review
Created: 6 Jul 2018, 12:42 p.m.
OriginaI Metadata from IUIS classification table (February, 2018) downloaded 20180614. IUIS Genetic defect (original gene symbol in IUIS download): HMOX .PanelApp HGNC gene symbol check: HMOX1 . IUIS Disease: Isolated congenital asplenia (ICA) due to HMOX deficiency . IUIS Inheritance: AR .T cells: N/A, .B cells: N/A, .IUIS Other affected cells: Macrophages. IUIS Associated features: Hemolysis, nephritis, inflammation. IUIS Major category: Defects in Intrinsic and Innate Immunity. IUIS Subcategory: Other Inborn Errors of Immunity Related to Non-Hematopoietic Tissues
Created: 6 Jul 2018, 12:20 p.m.

Sophie Hambleton (Newcastle University)

Red List (low evidence)

Only one report of asplenia as part of this syndrome (phenotype dominated by haemolysis, endothelial inflammation)
Created: 29 Jun 2018, 8:54 p.m.

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
haemolysis; nephritis; asplenia; amyloidosis

Publications

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
Phenotypes
  • amyloidosis
  • Hemolysis, nephritis, inflammation
  • Defects in Intrinsic and Innate Immunity
OMIM
141250
Clinvar variants
Variants in HMOX1
Penetrance
None
Publications
Panels with this gene

History Filter Activity

2 Apr 2020, Gel status: 3

Added New Source, Set Phenotypes, Status Update

Ellen McDonagh (Genomics England Curator)

Source Expert Review Green was added to HMOX1. Added phenotypes amyloidosis; Hemolysis, nephritis, inflammation; Defects in Intrinsic and Innate Immunity for gene: HMOX1 Rating Changed from Red List (low evidence) to Green List (high evidence)

1 Apr 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Ellen McDonagh (Genomics England Curator)

gene: HMOX1 was added gene: HMOX1 was added to Viral susceptibility. Sources: Expert Review Red,IUIS Classification February 2018 Mode of inheritance for gene: HMOX1 was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: HMOX1 were set to 21088618; 9884342 Phenotypes for gene: HMOX1 were set to amyloidosis; Hemolysis, nephritis, inflammation; Defects in Intrinsic and Innate Immunity