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COVID-19 research

Gene: CD209

Red List (low evidence)

CD209 (CD209 molecule)
EnsemblGeneIds (GRCh38): ENSG00000090659
EnsemblGeneIds (GRCh37): ENSG00000090659
OMIM: 604672, Gene2Phenotype
CD209 is in 2 panels

2 reviews

Alison Coffey (Illumina Clinical Services Laboratory, Illumina Inc.)

I don't know

Mode of inheritance
Unknown

Publications

Sarah Leigh (Genomics England Curator)

Red List (low evidence)

CD209 was identified through an OMIM search for potential viral susceptibility genes. Initial triage by Illumina (Alison Coffey and team) was given a Tier 3 grouping (experimental evidence and association data consistent with viral susceptibility). Illumina review: One SNP associated with susceptibility to HIV infection, severity of dengue disease, increased risk of TB and severity of SARS infection. Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. From OMIM:The C-type lectin receptors are involved in the primary interface between host and pathogens. PMID:15564514: Martin et al. (2004) - European Americans at risk for parenteral HIV infection were more likely to carry the -336C SNP in the promoter of DCSIGN. This association was not observed in those at risk for mucosally acquired infection. Although the -336C SNP was common in African Americans, no significant association with risk of infection was observed in this group. PMID:15838506: Sakuntabhai et al. (2005) found that the same CD209 promoter polymorphism reported by Martin et al. (2004) (-336A>G in this study), was associated with severity of dengue disease. Specifically, the G allele of the variant was associated with strong protection against dengue fever as opposed to dengue hemorrhagic fever. PMID:16379498:Barreiro et al. (2006) looked at CD209 polymorphisms in 351 TB patients and 360 healthy controls from a South African Coloured population living in communities with some of the highest reported incidence rates of TB in the world. Identified two variants in the CD209 promoter, -871A and -336G, that were associated with increased risk of TB. PMID:20864747: Chan et al. (2010) - A single nucleotide polymorphism in the promoter region of the DC-SIGN gene is associated with disease severity in SARS. In the DC_SIGN promoter region, a single SNP, -336A>G has been found to affect transcription of DC-SIGN in vitro and is associated with susceptibility for HIV-1 and M. tuberculosis infectsions and with the severity of dengue (PMID:15838506;15838506;16379498). Large case-control study - genotyped the SNP in 824 SARS patients and 471 controls. Showed no association with susceptibility to infection but SARS patients carrying the DC-SIGN promoter -336G variant had lower risk of having higher lactate dehydrogenase levels on admission, an independent prognostic indicator for severity of SARS-CoV infection. In vitro functional studies demonstrated that the DC-SIGN -336G promoter provided a less effective binding site and lower promoter activity, which may lead to reduced DC-SIGN protein expression and hence may contribute to a reduced immune-response with reduced lung injury during the progression of SARS infection.
Created: 11 Jun 2020, 6:10 p.m. | Last Modified: 12 Jun 2020, 10:05 a.m.
Panel Version: 1.15
Single variant associated with HIV susceptibility and Denge fever protection
Created: 4 May 2020, 3:17 p.m. | Last Modified: 4 May 2020, 3:17 p.m.
Panel Version: 0.176

Mode of inheritance
Unknown

Phenotypes
{Dengue fever, protection against} 614371; {HIV type 1, susceptibility to} 609423; {Mycobacterium tuberculosis, susceptibility to} 607948

Publications

Details

Sources
  • OMIM
Phenotypes
  • {Dengue fever, protection against} 614371
  • {HIV type 1, susceptibility to} 609423
  • {Mycobacterium tuberculosis, susceptibility to} 607948
OMIM
604672
Clinvar variants
Variants in CD209
Penetrance
None
Publications
Panels with this gene

History Filter Activity

12 Jun 2020, Gel status: 1

Set Phenotypes

Sarah Leigh (Genomics England Curator)

Phenotypes for gene: CD209 were changed from to {Dengue fever, protection against} 614371; {HIV type 1, susceptibility to} 609423; {Mycobacterium tuberculosis, susceptibility to} 607948

12 Jun 2020, Gel status: 1

Set publications

Sarah Leigh (Genomics England Curator)

Publications for gene: CD209 were set to

21 Apr 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance

Sarah Leigh (Genomics England Curator)

gene: CD209 was added gene: CD209 was added to Viral susceptibility. Sources: OMIM Mode of inheritance for gene: CD209 was set to