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STRs in panel
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COVID-19 research

Gene: SLX4

Green List (high evidence)

SLX4 (SLX4 structure-specific endonuclease subunit)
EnsemblGeneIds (GRCh38): ENSG00000188827
EnsemblGeneIds (GRCh37): ENSG00000188827
OMIM: 613278, Gene2Phenotype
SLX4 is in 19 panels

2 reviews

Sophie Hambleton (Newcastle University)

Green List (high evidence)

IUIS gene for Fanconi anaemia/bone marrow failure
Created: 5 May 2020, 10:42 a.m. | Last Modified: 5 May 2020, 10:42 a.m.
Panel Version: 0.180

Ivone Leong (Genomics England Curator)

Green List (high evidence)

IUIS: categorised under bone marrow failure with immune deficiency - Fanconi Anemia section. Inheritance AR. T cells: normal to low. B cells: normal to low. Other affected cells: HSC. Associated features: Normal to low NK, CNS, skeletal, skin, cardiac, GI, urogenital anomalies, increased chromosomal breakage.
Created: 15 Apr 2020, 12:09 p.m. | Last Modified: 15 Apr 2020, 12:09 p.m.
Panel Version: 0.103

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Fanconi anemia, complementation group P, 613951


History Filter Activity

15 Apr 2020, Gel status: 3

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Ivone Leong (Genomics England Curator)

gene: SLX4 was added gene: SLX4 was added to Viral susceptibility. Sources: Expert Review Green,IUIS Classification December 2019 Mode of inheritance for gene: SLX4 was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: SLX4 were set to 32086639; 32048120 Phenotypes for gene: SLX4 were set to Fanconi anemia, complementation group P, 613951