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COVID-19 research

Gene: MST1R

Red List (low evidence)

MST1R (macrophage stimulating 1 receptor)
EnsemblGeneIds (GRCh38): ENSG00000164078
EnsemblGeneIds (GRCh37): ENSG00000164078
OMIM: 600168, Gene2Phenotype
MST1R is in 1 panel

1 review

Rebecca Foulger (Genomics England curator)

Comment on list classification: Kept rating as Red for now: Possible involvement in viral-induced carcinomas, but most evidence for a role in the viral life cycle comes from animal models.
Created: 21 May 2020, 8:50 p.m. | Last Modified: 21 May 2020, 8:50 p.m.
Panel Version: 0.287
Comment on publications: Note that in the literature, MST1R is often referred to as RON for the human and Stk for the rodent orthologs.
Created: 21 May 2020, 8:49 p.m. | Last Modified: 21 May 2020, 8:49 p.m.
Panel Version: 0.286
PMID:22974584 Chou et al., 2012 demonstrate involvement of MST1R (RON) in Epstein-Barr virus (EBV)-associated Nasopharyngeal carcinoma (NPC).
Created: 21 May 2020, 8:48 p.m. | Last Modified: 21 May 2020, 8:48 p.m.
Panel Version: 0.285
PMID:15557181. Lee et al. (2004) proposed that HIV-1 may directly or indirectly target MST1R (RON) to disrupt normal signals that actively suppress inflammation to assure a microenvironment favorable for virus replication.
Created: 21 May 2020, 8:48 p.m. | Last Modified: 21 May 2020, 8:48 p.m.
Panel Version: 0.285
MST1R was identified through an OMIM search for potential viral susceptibility genes. Based on initial triage by Illumina (Tier 5 grouping) and additional curation, added to panel as Red.
Sources: Other
Created: 21 May 2020, 8:47 p.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Phenotypes
{Nasopharyngeal carcinoma, susceptibility to, 3}, 617075

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Sources
Phenotypes
  • {Nasopharyngeal carcinoma, susceptibility to, 3}, 617075
OMIM
600168
Clinvar variants
Variants in MST1R
Penetrance
None
Publications
Panels with this gene

History Filter Activity

21 May 2020, Gel status: 1

Entity classified by Genomics England curator

Rebecca Foulger (Genomics England curator)

Gene: mst1r has been classified as Red List (Low Evidence).

21 May 2020, Gel status: 1

Set publications

Rebecca Foulger (Genomics England curator)

Publications for gene: MST1R were set to 15557181; 22974584; 16527351

21 May 2020, Gel status: 1

Set publications

Rebecca Foulger (Genomics England curator)

Publications for gene: MST1R were set to

21 May 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Rebecca Foulger (Genomics England curator)

gene: MST1R was added gene: MST1R was added to COVID-19 research. Sources: Other Mode of inheritance for gene: MST1R was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown Phenotypes for gene: MST1R were set to {Nasopharyngeal carcinoma, susceptibility to, 3}, 617075