COVID-19 research
Gene: MST1RComment on list classification: Kept rating as Red for now: Possible involvement in viral-induced carcinomas, but most evidence for a role in the viral life cycle comes from animal models.Created: 21 May 2020, 8:50 p.m. | Last Modified: 21 May 2020, 8:50 p.m.
Panel Version: 0.287
Comment on publications: Note that in the literature, MST1R is often referred to as RON for the human and Stk for the rodent orthologs.Created: 21 May 2020, 8:49 p.m. | Last Modified: 21 May 2020, 8:49 p.m.
Panel Version: 0.286
PMID:22974584 Chou et al., 2012 demonstrate involvement of MST1R (RON) in Epstein-Barr virus (EBV)-associated Nasopharyngeal carcinoma (NPC).Created: 21 May 2020, 8:48 p.m. | Last Modified: 21 May 2020, 8:48 p.m.
Panel Version: 0.285
PMID:15557181. Lee et al. (2004) proposed that HIV-1 may directly or indirectly target MST1R (RON) to disrupt normal signals that actively suppress inflammation to assure a microenvironment favorable for virus replication.Created: 21 May 2020, 8:48 p.m. | Last Modified: 21 May 2020, 8:48 p.m.
Panel Version: 0.285
MST1R was identified through an OMIM search for potential viral susceptibility genes. Based on initial triage by Illumina (Tier 5 grouping) and additional curation, added to panel as Red.
Sources: OtherCreated: 21 May 2020, 8:47 p.m.
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Phenotypes
{Nasopharyngeal carcinoma, susceptibility to, 3}, 617075
Gene: mst1r has been classified as Red List (Low Evidence).
Publications for gene: MST1R were set to 15557181; 22974584; 16527351
Publications for gene: MST1R were set to
gene: MST1R was added gene: MST1R was added to COVID-19 research. Sources: Other Mode of inheritance for gene: MST1R was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown Phenotypes for gene: MST1R were set to {Nasopharyngeal carcinoma, susceptibility to, 3}, 617075