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COVID-19 research

Gene: OCLN

Red List (low evidence)

OCLN (occludin)
EnsemblGeneIds (GRCh38): ENSG00000197822
EnsemblGeneIds (GRCh37): ENSG00000197822
OMIM: 602876, Gene2Phenotype
OCLN is in 12 panels

1 review

Eleanor Williams (Genomics England Curator)

Red List (low evidence)

Not associated with any viral susceptibility phenotypes in OMIM.

Evidence that OCLN is involved in HCV cell entry

PMID: 19182773 - Ploss et al 2009 - show that human occludin is an essential HCV cell entry factor that is able to render murine cells infectable with HCVpp. Similarly, OCLN is required for the HCV-susceptibility of human cells, because its overexpression in uninfectable cells specifically enhanced HCVpp uptake, whereas its silencing in permissive cells impaired both HCVpp and HCVcc infection.

PMID: 31328852 - Lavie et al 2019 - looked at which residues in OCLN affect hepatitis C virus (HCV) entry. In the context of full-length OCLN, mutation of I279 and W281 residues only partially affected infection and cell surface localization.
Sources: Literature
Created: 21 May 2020, 10:38 p.m.

Mode of inheritance
Unknown

Publications

History Filter Activity

21 May 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications

Eleanor Williams (Genomics England Curator)

gene: OCLN was added gene: OCLN was added to COVID-19 research. Sources: Literature Mode of inheritance for gene: OCLN was set to Unknown Publications for gene: OCLN were set to 19182773; 31328852 Review for gene: OCLN was set to RED