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COVID-19 research

Gene: TMEM181

Red List (low evidence)

TMEM181 (transmembrane protein 181)
EnsemblGeneIds (GRCh38): ENSG00000146433
EnsemblGeneIds (GRCh37): ENSG00000146433
OMIM: 613209, Gene2Phenotype
TMEM181 is in 1 panel

1 review

Arina Puzriakova (Genomics England Curator)

Using UK Biobank data of 5,871 participants tested for COVID-19, including 193 deaths from 1,412 confirmed infections, authors identified 5 risk variants in 4 genes (ERAP2, BRF2, TMEM181, ALOXE3) associated with death from SARS-CoV-2 infection.

TMEM181 SNP (rs117665206, R403C). Authors state that this could be a potentially druggable target for treatment with Cysteamine in COVID-19 patients with this variant. However, whether this genetic variant has any physiological role on SARS-CoV-2 infection is yet to be determined.
Sources: Literature
Created: 29 Jul 2020, 2:49 p.m.

Mode of inheritance


Mode of Inheritance
  • Literature
Clinvar variants
Variants in TMEM181
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29 Jul 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance

Arina Puzriakova (Genomics England Curator)

gene: TMEM181 was added gene: TMEM181 was added to COVID-19 research. Sources: Literature Mode of inheritance for gene: TMEM181 was set to Unknown