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COVID-19 research

Gene: LDLR

Red List (low evidence)

LDLR (low density lipoprotein receptor)
EnsemblGeneIds (GRCh38): ENSG00000130164
EnsemblGeneIds (GRCh37): ENSG00000130164
OMIM: 606945, Gene2Phenotype
LDLR is in 11 panels

1 review

Sarah Leigh (Genomics England Curator)

Red List (low evidence)

Loss of LDLR from the cell surface results in resistance to viral infection (PMID 10535997, 31386864, 31358055).
Created: 2 Jun 2020, 4:14 p.m. | Last Modified: 2 Jun 2020, 4:14 p.m.
Panel Version: 1.1
Hepatitis C virus (HCV) and other viruses can enter cells via LDLR mediated endocytosis (PMID 32268133). PMID 10535997 demonstrates that lack of detectable LDL receptor on cells results in resistance to infection by bovine viral diarrheal virus. Dengue virus genome replication and protein synthesis was significantly inhibited by the serine protease inhibitor AEBSF [4-(2-aminoethyl) benzene sulfonyl fluoride] that inhibits the expression of genes HMGCS, HMGCR & LDLR (PMID 31386864). A recent LDLR-null FH cell model has been developed, which is permisive to HCV infection, but virus production was significantly decreased compared with cells in which the LDLR activity had been corrected to normal levels (PMID 31358055).
Created: 4 May 2020, 3:17 p.m. | Last Modified: 4 May 2020, 3:17 p.m.
Panel Version: 0.176

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Hypercholesterolemia, familial, 1 143890; LDL cholesterol level QTL2 143890


History Filter Activity

21 Apr 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance

Sarah Leigh (Genomics England Curator)

gene: LDLR was added gene: LDLR was added to Viral susceptibility. Sources: OMIM Mode of inheritance for gene: LDLR was set to