Genes in panel
STRs in panel
Prev Next

COVID-19 research

Gene: ALOXE3

Red List (low evidence)

ALOXE3 (arachidonate lipoxygenase 3)
EnsemblGeneIds (GRCh38): ENSG00000179148
EnsemblGeneIds (GRCh37): ENSG00000179148
OMIM: 607206, Gene2Phenotype
ALOXE3 is in 9 panels

1 review

Arina Puzriakova (Genomics England Curator)

Using UK Biobank data of 5,871 participants tested for COVID-19, including 193 deaths from 1,412 confirmed infections, authors identified 5 novel risk variants in 4 genes (ERAP2, BRF2, TMEM181, ALOXE3) associated with death from SARS-CoV-2 infection.

Two ALOXE3 SNP (rs147149459, rs151256885) identified. Furthermore, it has been shown that ALOXE3 is upregulated by SARS-CoV in human airway epithelial cultures. However, whether genetic variants have any physiological role on SARS-CoV-2 infection is yet to be determined.
Sources: Literature
Created: 29 Jul 2020, 1:57 p.m.

Mode of inheritance

History Filter Activity

29 Jul 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance

Arina Puzriakova (Genomics England Curator)

gene: ALOXE3 was added gene: ALOXE3 was added to COVID-19 research. Sources: Literature Mode of inheritance for gene: ALOXE3 was set to Unknown