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COVID-19 research

Gene: GC

Amber List (moderate evidence)

GC (GC, vitamin D binding protein)
EnsemblGeneIds (GRCh38): ENSG00000145321
EnsemblGeneIds (GRCh37): ENSG00000145321
OMIM: 139200, Gene2Phenotype
GC is in 1 panel

3 reviews

Sarah Leigh (Genomics England Curator)

GC was identified through an OMIM search for potential viral susceptibility genes. Initial triage by Illumina (Alison Coffey and team) was given a Tier 3 grouping (experimental evidence and association data consistent with viral susceptibility)
Created: 11 Jun 2020, 6:10 p.m. | Last Modified: 11 Jun 2020, 6:10 p.m.
Panel Version: 1.10

Alison Coffey (Illumina Clinical Services Laboratory, Illumina Inc.)

Red List (low evidence)

Conflicting evidence for association of GC1f allele with susceptibility to HIV disease progression (PMID: 2883392; 2895851 and Gilles et al. 1987 and Daiger et al. 1987 - no PMIDs).
Created: 11 Jun 2020, 5:58 p.m. | Last Modified: 11 Jun 2020, 5:58 p.m.
Panel Version: 1.9

Mode of inheritance
Unknown

Publications

Rebecca Foulger (Genomics England curator)

Identified through an OMIM search for potential viral susceptibility genes, and subsequently triaged/reviewed by Illumina curation team.
Created: 2 Jun 2020, 1:53 p.m. | Last Modified: 2 Jun 2020, 1:53 p.m.
Panel Version: 1.1

Details

Mode of Inheritance
Unknown
Sources
OMIM
139200
Clinvar variants
Variants in GC
Penetrance
None
Panels with this gene

History Filter Activity

2 Jun 2020, Gel status: 2

Created, Added New Source, Set mode of inheritance

Rebecca Foulger (Genomics England curator)

gene: GC was added gene: GC was added to COVID-19 research. Sources: OMIM,Expert list,Expert Review Amber Mode of inheritance for gene: GC was set to Unknown