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COVID-19 research

Gene: NOS2

Green List (high evidence)

NOS2 (nitric oxide synthase 2)
EnsemblGeneIds (GRCh38): ENSG00000007171
EnsemblGeneIds (GRCh37): ENSG00000007171
OMIM: 163730, Gene2Phenotype
NOS2 is in 3 panels

2 reviews

Sophie Hambleton (Newcastle University)

Green List (high evidence)

Level of evidence would not support automatic inclusion on a diagnostic panel
Created: 1 May 2020, 11:17 a.m. | Last Modified: 1 May 2020, 11:17 a.m.
Panel Version: 0.171

Ivone Leong (Genomics England Curator)

Green List (high evidence)

NOS2 is part of the list of genes that confer susceptibility to viral infections on the COVID Human Genetic Effort website (

PMID: 31995689 describes a 51 year old man from Iran who had an acute cytomegalovirus (CMV) infection which progressed to CMV disease and later died from it. The researchers found a homozygous variant that causes a frameshift mutation in NOS2 that caused NOS2 deficiency, which might cause the patient to be more susceptible to lethal CMV infection. It is rare for CMV to cause fatality in healthy people; however, Nos2 knockout mice are susceptible to lethal infection with murine CMV (PMID: 11207313).

Based on the above evidence NOS2 has been given Green gene status.
Sources: Expert list
Created: 21 Apr 2020, 11:17 a.m.

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal



Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
  • Expert Review Green
  • Expert list
Clinvar variants
Variants in NOS2
Panels with this gene

History Filter Activity

21 Apr 2020, Gel status: 3

Entity classified by Genomics England curator

Ivone Leong (Genomics England Curator)

Gene: nos2 has been classified as Green List (High Evidence).

21 Apr 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications

Ivone Leong (Genomics England Curator)

gene: NOS2 was added gene: NOS2 was added to Viral susceptibility. Sources: Expert list Mode of inheritance for gene: NOS2 was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: NOS2 were set to 31995689; 11207313 Review for gene: NOS2 was set to GREEN