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COVID-19 research

Gene: IRF7

Green List (high evidence)

IRF7 (interferon regulatory factor 7)
EnsemblGeneIds (GRCh38): ENSG00000185507
EnsemblGeneIds (GRCh37): ENSG00000185507
OMIM: 605047, Gene2Phenotype
IRF7 is in 4 panels

3 reviews

Sophie Hambleton (Newcastle University)

I don't know

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Severe influenza

Publications

Louise Daugherty (Genomics England Curator)

I don't know

OriginaI Metadata from IUIS classification table (February, 2018) downloaded 20180614. IUIS Genetic defect (original gene symbol in IUIS download): IRF7 .PanelApp HGNC gene symbol check: IRF7 . IUIS Disease: IRF7 deficiency . IUIS Inheritance: AR .T cells: Normal or decreased CD4 numbers, T cell dysregulation, .B cells: N/A, .IUIS Other affected cells: Leukocytes, plasmacytoid dendritic cells, Non-hematopoietic cells. IUIS Associated features: Severe influenza disease . IUIS Major category: Defects in Intrinsic and Innate Immunity. IUIS Subcategory: Predisposition to Severe Viral Infection
Created: 2 Jul 2018, 10:35 a.m.
Comment on list classification: Keep Amber until more info on gene and disease association, Interferon regulation shown in one family (two affecteds), request evidences from GRID and Victorian Clinical Genetics Services
Created: 21 Jun 2018, 9:58 p.m.
Comment on publications: Added publications suggested from external expert review to support upgrading of the gene to Amber- only one family, two cases
Created: 21 Jun 2018, 9:31 p.m.
This gene was absent from the original PanelApp PID panel dataset (review April 2018). However it was listed in external expert immunodeficiency diagnostic gene list(s) GOSH or GRID. In this combined PID panel, this gene has been rated as AMBER and needs further curational review to assess pertinence prior to v1.
Created: 20 Apr 2018, 12:25 p.m.
Original metadata supplied by GRID. GRID Gene Symbol HGNC PanelApp check: IRF7, GRID_Gene_Symbol: IRF7, GRID_Transcript_ENS_Community submitted: ENST00000397566, GRID_Transcript_RefSeq: NM_001572.3, GRID_Transcript_ENS_used_on_Production: ENST00000397566
Created: 17 Apr 2018, 12:12 p.m.

Ellen McDonagh (Genomics England Curator)

Mode of inheritance
Unknown

Phenotypes
Severe influenza

Publications

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Literature
Phenotypes
  • Severe influenza
  • ?Immunodeficiency 39, 616345
  • Severe influenza disease
  • IRF7 deficiency
  • Defects in Intrinsic and Innate Immunity
OMIM
605047
Clinvar variants
Variants in IRF7
Penetrance
Complete
Publications
Panels with this gene

History Filter Activity

30 Apr 2020, Gel status: 3

Set publications

Rebecca Foulger (Genomics England curator)

Publications for gene: IRF7 were set to 26761402; 9315633; 32086639; 25814066; 32048120; 26621750; 31154625

30 Apr 2020, Gel status: 3

Set publications

Rebecca Foulger (Genomics England curator)

Publications for gene: IRF7 were set to 26761402; 9315633; 32086639; 25814066; 32048120; 26621750

2 Apr 2020, Gel status: 3

Set Phenotypes, Set publications

Ellen McDonagh (Genomics England Curator)

Added phenotypes Severe influenza; ?Immunodeficiency 39, 616345; Severe influenza disease; IRF7 deficiency; Defects in Intrinsic and Innate Immunity for gene: IRF7 Publications for gene IRF7 were updated from 26761402; 9315633; 32086639; 25814066; 32048120; 26621750 to 26761402; 9315633; 32086639; 25814066; 32048120; 26621750

1 Apr 2020, Gel status: 3

Set mode of inheritance, Set Phenotypes, Set publications

Ellen McDonagh (Genomics England Curator)

Mode of inheritance for gene IRF7 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal Added phenotypes Severe influenza; ?Immunodeficiency 39, 616345; Severe influenza disease; IRF7 deficiency; Defects in Intrinsic and Innate Immunity for gene: IRF7 Publications for gene IRF7 were updated from 26621750 to 26761402; 9315633; 32086639; 25814066; 32048120; 26621750

31 Mar 2020, Gel status: 3

Added New Source, Added New Source, Added New Source, Status Update

Ellen McDonagh (Genomics England Curator)

Source Melbourne Genomics Health Alliance Immunology Flagship was added to IRF7. Source Victorian Clinical Genetics Services was added to IRF7. Source Expert Review Green was added to IRF7. Rating Changed from Red List (low evidence) to Green List (high evidence)

14 Mar 2017, Gel status: 0

Added New Source

Ellen McDonagh (Genomics England Curator)

IRF7 was added to Monogenic viral susceptibilitypanel. Sources: Literature

14 Mar 2017, Gel status: 0

Created

Ellen McDonagh (Genomics England Curator)

IRF7 was created by ellenmcdonagh