COVID-19 research
Gene: IRF7
Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal
Phenotypes
Severe influenza
Publications
OriginaI Metadata from IUIS classification table (February, 2018) downloaded 20180614. IUIS Genetic defect (original gene symbol in IUIS download): IRF7 .PanelApp HGNC gene symbol check: IRF7 . IUIS Disease: IRF7 deficiency . IUIS Inheritance: AR .T cells: Normal or decreased CD4 numbers, T cell dysregulation, .B cells: N/A, .IUIS Other affected cells: Leukocytes, plasmacytoid dendritic cells, Non-hematopoietic cells. IUIS Associated features: Severe influenza disease . IUIS Major category: Defects in Intrinsic and Innate Immunity. IUIS Subcategory: Predisposition to Severe Viral InfectionCreated: 2 Jul 2018, 10:35 a.m.
Comment on list classification: Keep Amber until more info on gene and disease association, Interferon regulation shown in one family (two affecteds), request evidences from GRID and Victorian Clinical Genetics ServicesCreated: 21 Jun 2018, 9:58 p.m.
Comment on publications: Added publications suggested from external expert review to support upgrading of the gene to Amber- only one family, two casesCreated: 21 Jun 2018, 9:31 p.m.
This gene was absent from the original PanelApp PID panel dataset (review April 2018). However it was listed in external expert immunodeficiency diagnostic gene list(s) GOSH or GRID. In this combined PID panel, this gene has been rated as AMBER and needs further curational review to assess pertinence prior to v1.Created: 20 Apr 2018, 12:25 p.m.
Original metadata supplied by GRID. GRID Gene Symbol HGNC PanelApp check: IRF7, GRID_Gene_Symbol: IRF7, GRID_Transcript_ENS_Community submitted: ENST00000397566, GRID_Transcript_RefSeq: NM_001572.3, GRID_Transcript_ENS_used_on_Production: ENST00000397566Created: 17 Apr 2018, 12:12 p.m.
Mode of inheritance
Unknown
Phenotypes
Severe influenza
Publications
Source: Expert Review Amber was removed from gene: IRF7
Publications for gene: IRF7 were set to 26761402; 9315633; 32086639; 25814066; 32048120; 26621750; 31154625
Publications for gene: IRF7 were set to 26761402; 9315633; 32086639; 25814066; 32048120; 26621750
Added phenotypes Severe influenza; ?Immunodeficiency 39, 616345; Severe influenza disease; IRF7 deficiency; Defects in Intrinsic and Innate Immunity for gene: IRF7 Publications for gene IRF7 were updated from 26761402; 9315633; 32086639; 25814066; 32048120; 26621750 to 26761402; 9315633; 32086639; 25814066; 32048120; 26621750
Mode of inheritance for gene IRF7 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal Added phenotypes Severe influenza; ?Immunodeficiency 39, 616345; Severe influenza disease; IRF7 deficiency; Defects in Intrinsic and Innate Immunity for gene: IRF7 Publications for gene IRF7 were updated from 26621750 to 26761402; 9315633; 32086639; 25814066; 32048120; 26621750
Source Melbourne Genomics Health Alliance Immunology Flagship was added to IRF7. Source Victorian Clinical Genetics Services was added to IRF7. Source Expert Review Green was added to IRF7. Rating Changed from Red List (low evidence) to Green List (high evidence)
IRF7 was added to Monogenic viral susceptibilitypanel. Sources: Literature
IRF7 was created by ellenmcdonagh