COVID-19 research
Gene: FCGR2A
Has been identified as a risk loci for Kawasaki disease.Created: 13 May 2020, 4:54 p.m. | Last Modified: 13 May 2020, 4:54 p.m.
Panel Version: 0.227
The FCGR2A high/low-responder polymorphism influences susceptibility to infections, dependent on R or H at position 131.
PMID: 19494086 - associated with severe sepsis in community-acquired pneumonia. R/R131 genotype was found more frequently in patients with severe sepsis
PMID: 12752683 - FCGR2A polymorphisms in Streptococcus pneumoniae infection. The frequency of homozygosity for FCGR2A-R/R131 in the patients was significantly higher than that in the healthy random donor population
PMID: 16185324 Found a significant association was found between the FCGR2A -R/R131 genotype and a severe course of SARS, with higher frequency of homozygosity for FCGR2A -R/R131 in the ICU subgroup of SARS patients when compared with controls
There are also studies reporting on this polymorphism in studies associated with HIV, dengue fever (PMID:12363051) and periodontitis (PMID: 17877745)which found that periodontal destruction occurs in the H/H genotype.Created: 8 Apr 2020, 10:19 a.m. | Last Modified: 8 Apr 2020, 10:19 a.m.
Panel Version: 0.67
Mode of inheritance
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Publications
PMID: 16185324 reports an association between polymorphisms in this gene and the severity of SARS-Cov infection.
Sources: LiteratureCreated: 30 Mar 2020, 4:24 p.m.
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Phenotypes
Severity of severe acute respiratory syndrome (SARS) SARS-Cov
Publications
Not linked to Mendelian immune disorderCreated: 11 Jun 2018, 2:28 p.m.
External expert review notes Red status due to no evident link to Mendelian immunodeficiency, so I have kept this gene Red on this panelCreated: 12 Jun 2018, 12:48 p.m.
Original metadata downloaded from ESID Registry. ESID_Gene_original: FCGR2A, PanelApp HGNC gene symbol check: FCGR2A, ESID classification: Main_category/ Sub_category/ PID_Diagnosis Other well defined PIDs / Fc receptor deficiencies / Fc receptor deficienciesCreated: 17 Apr 2018, 12:29 p.m.
Publications for gene: FCGR2A were set to 16185324
Mode of inheritance for gene: FCGR2A was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Gene: fcgr2a has been classified as Green List (High Evidence).
Tag watchlist tag was added to gene: FCGR2A. Tag polygenic tag was added to gene: FCGR2A.
Mode of inheritance for gene FCGR2A was changed from MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown to Unknown Added phenotypes Fc receptor deficiencies for gene: FCGR2A
Phenotypes for gene: FCGR2A were changed from Severity of severe acute respiratory syndrome (SARS) SARS-Cov to Severity of severe acute respiratory syndrome (SARS)-Cov infection
gene: FCGR2A was added gene: FCGR2A was added to Viral susceptibility. Sources: Literature Mode of inheritance for gene: FCGR2A was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown Publications for gene: FCGR2A were set to 16185324 Phenotypes for gene: FCGR2A were set to Severity of severe acute respiratory syndrome (SARS) SARS-Cov