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COVID-19 research

Gene: FCGR2A

Green List (high evidence)

FCGR2A (Fc fragment of IgG receptor IIa)
EnsemblGeneIds (GRCh38): ENSG00000143226
EnsemblGeneIds (GRCh37): ENSG00000143226
OMIM: 146790, Gene2Phenotype
FCGR2A is in 2 panels

4 reviews

Catherine Snow (Genomics England)

Green List (high evidence)

Has been identified as a risk loci for Kawasaki disease.
Created: 13 May 2020, 4:54 p.m. | Last Modified: 13 May 2020, 4:54 p.m.
Panel Version: 0.227
The FCGR2A high/low-responder polymorphism influences susceptibility to infections, dependent on R or H at position 131.

PMID: 19494086 - associated with severe sepsis in community-acquired pneumonia. R/R131 genotype was found more frequently in patients with severe sepsis
PMID: 12752683 - FCGR2A polymorphisms in Streptococcus pneumoniae infection. The frequency of homozygosity for FCGR2A-R/R131 in the patients was significantly higher than that in the healthy random donor population

PMID: 16185324 Found a significant association was found between the FCGR2A -R/R131 genotype and a severe course of SARS, with higher frequency of homozygosity for FCGR2A -R/R131 in the ICU subgroup of SARS patients when compared with controls

There are also studies reporting on this polymorphism in studies associated with HIV, dengue fever (PMID:12363051) and periodontitis (PMID: 17877745)which found that periodontal destruction occurs in the H/H genotype.
Created: 8 Apr 2020, 10:19 a.m. | Last Modified: 8 Apr 2020, 10:19 a.m.
Panel Version: 0.67

Mode of inheritance
BOTH monoallelic and biallelic, autosomal or pseudoautosomal

Publications

Ellen McDonagh (Genomics England Curator)

PMID: 16185324 reports an association between polymorphisms in this gene and the severity of SARS-Cov infection.
Sources: Literature
Created: 30 Mar 2020, 4:24 p.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Phenotypes
Severity of severe acute respiratory syndrome (SARS) SARS-Cov

Publications

Sophie Hambleton (Newcastle University)

Red List (low evidence)

Not linked to Mendelian immune disorder
Created: 11 Jun 2018, 2:28 p.m.

Louise Daugherty (Genomics England Curator)

I don't know

External expert review notes Red status due to no evident link to Mendelian immunodeficiency, so I have kept this gene Red on this panel
Created: 12 Jun 2018, 12:48 p.m.
Original metadata downloaded from ESID Registry. ESID_Gene_original: FCGR2A, PanelApp HGNC gene symbol check: FCGR2A, ESID classification: Main_category/ Sub_category/ PID_Diagnosis Other well defined PIDs / Fc receptor deficiencies / Fc receptor deficiencies
Created: 17 Apr 2018, 12:29 p.m.

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Sources
  • Expert Review Green
Phenotypes
  • Fc receptor deficiencies
  • Severity of severe acute respiratory syndrome (SARS)-Cov infection
Tags
watchlist polygenic
OMIM
146790
Clinvar variants
Variants in FCGR2A
Penetrance
None
Publications
Panels with this gene

History Filter Activity

8 Apr 2020, Gel status: 3

Set publications

Catherine Snow (Genomics England)

Publications for gene: FCGR2A were set to 16185324

8 Apr 2020, Gel status: 3

Set mode of inheritance

Catherine Snow (Genomics England)

Mode of inheritance for gene: FCGR2A was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

8 Apr 2020, Gel status: 3

Entity classified by Genomics England curator

Catherine Snow (Genomics England)

Gene: fcgr2a has been classified as Green List (High Evidence).

8 Apr 2020, Gel status: 1

Added Tag, Added Tag

Catherine Snow (Genomics England)

Tag watchlist tag was added to gene: FCGR2A. Tag polygenic tag was added to gene: FCGR2A.

1 Apr 2020, Gel status: 1

Set mode of inheritance, Set Phenotypes

Ellen McDonagh (Genomics England Curator)

Mode of inheritance for gene FCGR2A was changed from MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown to Unknown Added phenotypes Fc receptor deficiencies for gene: FCGR2A

30 Mar 2020, Gel status: 1

Set Phenotypes

Ellen McDonagh (Genomics England Curator)

Phenotypes for gene: FCGR2A were changed from Severity of severe acute respiratory syndrome (SARS) SARS-Cov to Severity of severe acute respiratory syndrome (SARS)-Cov infection

30 Mar 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Ellen McDonagh (Genomics England Curator)

gene: FCGR2A was added gene: FCGR2A was added to Viral susceptibility. Sources: Literature Mode of inheritance for gene: FCGR2A was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown Publications for gene: FCGR2A were set to 16185324 Phenotypes for gene: FCGR2A were set to Severity of severe acute respiratory syndrome (SARS) SARS-Cov