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COVID-19 research

Gene: EGFR

Green List (high evidence)

EGFR (epidermal growth factor receptor)
EnsemblGeneIds (GRCh38): ENSG00000146648
EnsemblGeneIds (GRCh37): ENSG00000146648
OMIM: 131550, Gene2Phenotype
EGFR is in 5 panels

2 reviews

Catherine Snow (Genomics England)

Venkataraman et al (PMID 28390872) summary article on SARS-CoV but also include review evidence from their lab and others that pulmonary fibrosis is caused by a hyperactive host response to lung injury mediated by epidermal growth factor receptor (EGFR) signaling.

Mitchell et al (PMID: 31616667) states that EGFR is important during influenza infection, but the role it plays changes for lethal versus non-lethal infections
Created: 28 May 2020, 3:25 p.m. | Last Modified: 28 May 2020, 3:25 p.m.
Panel Version: 0.348

Publications

Rebecca Foulger (Genomics England curator)

Identified through an OMIM search for potential viral susceptibility genes, and subsequently triaged/reviewed by Illumina curation team.
Created: 28 May 2020, 12:36 p.m. | Last Modified: 28 May 2020, 12:36 p.m.
Panel Version: 0.336

History Filter Activity

28 May 2020, Gel status: 3

Set publications

Catherine Snow (Genomics England)

Publications for gene: EGFR were set to

28 May 2020, Gel status: 3

Created, Added New Source, Set mode of inheritance

Rebecca Foulger (Genomics England curator)

gene: EGFR was added gene: EGFR was added to COVID-19 research. Sources: Expert list,OMIM,Expert Review Green Mode of inheritance for gene: EGFR was set to Unknown