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COVID-19 research

Gene: ERAP2

Red List (low evidence)

ERAP2 (endoplasmic reticulum aminopeptidase 2)
EnsemblGeneIds (GRCh38): ENSG00000164308
EnsemblGeneIds (GRCh37): ENSG00000164308
OMIM: 609497, Gene2Phenotype
ERAP2 is in 1 panel

1 review

Arina Puzriakova (Genomics England Curator)

Using UK Biobank data of 5,871 participants tested for COVID-19, including 193 deaths from 1,412 confirmed infections, authors identified 5 risk variants in 4 genes (ERAP2, BRF2, TMEM181, ALOXE3) associated with death from SARS-CoV-2 infection.

The ERAP2 SNP (rs150892504, R751C) was disruptive to the fold of the protein, in turn decreasing stability. Authors state that this could be a potentially druggable target for treatment with Cysteamine in COVID-19 patients with this variant. However, whether this genetic variant has any physiological role on SARS-CoV-2 infection is yet to be determined.
Sources: Literature
Created: 29 Jul 2020, 12:49 p.m. | Last Modified: 29 Jul 2020, 1:06 p.m.
Panel Version: 1.64

Mode of inheritance


Mode of Inheritance
  • Literature
Clinvar variants
Variants in ERAP2
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History Filter Activity

29 Jul 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance

Arina Puzriakova (Genomics England Curator)

gene: ERAP2 was added gene: ERAP2 was added to COVID-19 research. Sources: Literature Mode of inheritance for gene: ERAP2 was set to Unknown