COVID-19 researchGene: MRC1
Comment on list classification: Updated rating from Red to Amber. Functional data in PMID:12645947 shows role of MRC1 in binding HIV-1, and PMID:24969847 shows association of MRC1 SNP and sustained viral response to Hepatitis-C virus. Papers also demonstrate variants are associated with susceptibility to other infectious diseases including leprosy (PMID:22392581) and pulmonary tuburculosis (PMID:23653008, 22393309).
Created: 21 May 2020, 4:51 p.m. | Last Modified: 21 May 2020, 4:56 p.m.
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PMID:24969847. Peng et al., 2014 evaluated whether polymorphisms of MRC-1 and IL-28B genes are associated with the treatment outcome of patients infected with hepatitis C (HCV). Among the MRC-1 SNPs, rs691005 was found to be associated with sustained viral responses (SVR) in HCV-1-infected patients.
Created: 21 May 2020, 4:50 p.m. | Last Modified: 21 May 2020, 4:50 p.m.
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PMID:12645947. Nguyen and Hildreth (2003) showed that MRC1 (also called MMR) mediated the initial association of human immunodeficiency virus with macrophages lacking expression of DCSIGN, concluding that MRC1 (MMR) has a substantial role in binding and transmission of HIV-1 by macrophages.
Created: 21 May 2020, 4:42 p.m. | Last Modified: 21 May 2020, 4:42 p.m.
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MRC1 was identified through an OMIM search for potential viral susceptibility genes. Added to panel based on initial triage by Illumina (Tier 5 grouping) and additional curation. Notes from Julie Taylor and Alison Coffey (Illumina): One function of the receptor is to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi, so that they can be neutralized by phagocytic engulfment.
Created: 21 May 2020, 4:38 p.m. | Last Modified: 21 May 2020, 4:44 p.m.
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Mode of inheritance
Publications for gene: MRC1 were set to 12645947; 24016730; 24969847
Gene: mrc1 has been classified as Amber List (Moderate Evidence).
Publications for gene: MRC1 were set to 12645947; 24016730
Publications for gene: MRC1 were set to 12645947
Publications for gene: MRC1 were set to
gene: MRC1 was added gene: MRC1 was added to COVID-19 research. Sources: Other Mode of inheritance for gene: MRC1 was set to Unknown