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COVID-19 research

Gene: MRC1

Amber List (moderate evidence)

MRC1 (mannose receptor C-type 1)
EnsemblGeneIds (GRCh38): ENSG00000260314
EnsemblGeneIds (GRCh37): ENSG00000120586
OMIM: 153618, Gene2Phenotype
MRC1 is in 1 panel

1 review

Rebecca Foulger (Genomics England curator)

Comment on list classification: Updated rating from Red to Amber. Functional data in PMID:12645947 shows role of MRC1 in binding HIV-1, and PMID:24969847 shows association of MRC1 SNP and sustained viral response to Hepatitis-C virus. Papers also demonstrate variants are associated with susceptibility to other infectious diseases including leprosy (PMID:22392581) and pulmonary tuburculosis (PMID:23653008, 22393309).
Created: 21 May 2020, 4:51 p.m. | Last Modified: 21 May 2020, 4:56 p.m.
Panel Version: 0.283
PMID:24969847. Peng et al., 2014 evaluated whether polymorphisms of MRC-1 and IL-28B genes are associated with the treatment outcome of patients infected with hepatitis C (HCV). Among the MRC-1 SNPs, rs691005 was found to be associated with sustained viral responses (SVR) in HCV-1-infected patients.
Created: 21 May 2020, 4:50 p.m. | Last Modified: 21 May 2020, 4:50 p.m.
Panel Version: 0.280
PMID:12645947. Nguyen and Hildreth (2003) showed that MRC1 (also called MMR) mediated the initial association of human immunodeficiency virus with macrophages lacking expression of DCSIGN, concluding that MRC1 (MMR) has a substantial role in binding and transmission of HIV-1 by macrophages.
Created: 21 May 2020, 4:42 p.m. | Last Modified: 21 May 2020, 4:42 p.m.
Panel Version: 0.278
MRC1 was identified through an OMIM search for potential viral susceptibility genes. Added to panel based on initial triage by Illumina (Tier 5 grouping) and additional curation. Notes from Julie Taylor and Alison Coffey (Illumina): One function of the receptor is to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi, so that they can be neutralized by phagocytic engulfment.
Sources: Other
Created: 21 May 2020, 4:38 p.m. | Last Modified: 21 May 2020, 4:44 p.m.
Panel Version: 0.280

Mode of inheritance
Unknown

Details

Mode of Inheritance
Unknown
Sources
OMIM
153618
Clinvar variants
Variants in MRC1
Penetrance
None
Publications
Panels with this gene

History Filter Activity

21 May 2020, Gel status: 2

Set publications

Rebecca Foulger (Genomics England curator)

Publications for gene: MRC1 were set to 12645947; 24016730; 24969847

21 May 2020, Gel status: 2

Entity classified by Genomics England curator

Rebecca Foulger (Genomics England curator)

Gene: mrc1 has been classified as Amber List (Moderate Evidence).

21 May 2020, Gel status: 1

Set publications

Rebecca Foulger (Genomics England curator)

Publications for gene: MRC1 were set to 12645947; 24016730

21 May 2020, Gel status: 1

Set publications

Rebecca Foulger (Genomics England curator)

Publications for gene: MRC1 were set to 12645947

21 May 2020, Gel status: 1

Set publications

Rebecca Foulger (Genomics England curator)

Publications for gene: MRC1 were set to

21 May 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance

Rebecca Foulger (Genomics England curator)

gene: MRC1 was added gene: MRC1 was added to COVID-19 research. Sources: Other Mode of inheritance for gene: MRC1 was set to Unknown