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COVID-19 research

Gene: STAT6

Red List (low evidence)

STAT6 (signal transducer and activator of transcription 6)
EnsemblGeneIds (GRCh38): ENSG00000166888
EnsemblGeneIds (GRCh37): ENSG00000166888
OMIM: 601512, Gene2Phenotype
STAT6 is in 1 panel

1 review

Ivone Leong (Genomics England Curator)

Red List (low evidence)

Immune system gene: STAT6 mediates immune signaling in response to cytokines at the plasma membrane and to virus infection at the endoplasmic reticulum. Mice lacking Stat6 were susceptible to virus infection. Chen et al. (2011) (PMID: 22000020).

PMID: 21762972 found that STAT6 increases viral replication in the skin of patients with atopic dermatitis (chronic inflammatory skin disease) with a history of eczema herpeticum.
Sources: Expert list
Created: 26 May 2020, 9:55 a.m.

Mode of inheritance



Mode of Inheritance
  • Expert list
Clinvar variants
Variants in STAT6
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History Filter Activity

26 May 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications

Ivone Leong (Genomics England Curator)

gene: STAT6 was added gene: STAT6 was added to COVID-19 research. Sources: Expert list Mode of inheritance for gene: STAT6 was set to Unknown Publications for gene: STAT6 were set to 22000020; 21762972 Review for gene: STAT6 was set to RED