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COVID-19 research

Gene: NCR3

Red List (low evidence)

NCR3 (natural cytotoxicity triggering receptor 3)
EnsemblGeneIds (GRCh38): ENSG00000204475
EnsemblGeneIds (GRCh37): ENSG00000204475
OMIM: 611550, Gene2Phenotype
NCR3 is in 1 panel

1 review

Eleanor Williams (Genomics England Curator)

Red List (low evidence)

Associated with {Malaria, mild, susceptibility to} #609148 in OMIM. It is also known as NKp30.

Evidence that level of NCR3/NKp30 expression is reduced in those infected with virus, and increased in those who remain uninfected. No reports that SNVs in the NCR3 gene affect suceptibility to viral infection.

PMID: 26094914 - Mantovani et al 2015 - six different splice variants of the NKp30-encoding gene NCR3, which are known to be expressed on the cell surface. NKp30 receptor expression on NK cells and all isoforms were reduced in chronic hepatitis C virus(HCV)-infected patients.

PMID: 24845613 - Sugden et al 2014 - enhanced expression of NKp30 on NK cells resulted in protection from developing HCV infection in multiply exposed uninfected individuals

PMID: 30325780 - Lucar et al 2019 - report in HIV-2 patients a very significant reduced expression of the activating NKp30 receptor on NK cells.
Sources: Literature
Created: 21 May 2020, 10:07 p.m.

Mode of inheritance

{Malaria, mild, susceptibility to}, 609148



Mode of Inheritance
  • Literature
  • {Malaria, mild, susceptibility to}, 609148
Clinvar variants
Variants in NCR3
Panels with this gene

History Filter Activity

21 May 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Eleanor Williams (Genomics England Curator)

gene: NCR3 was added gene: NCR3 was added to COVID-19 research. Sources: Literature Mode of inheritance for gene: NCR3 was set to Unknown Publications for gene: NCR3 were set to 26094914; 24845613; 30325780 Phenotypes for gene: NCR3 were set to {Malaria, mild, susceptibility to}, 609148 Review for gene: NCR3 was set to RED