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COVID-19 research

Gene: MIF

Amber List (moderate evidence)

MIF (macrophage migration inhibitory factor)
EnsemblGeneIds (GRCh38): ENSG00000240972
EnsemblGeneIds (GRCh37): ENSG00000240972
OMIM: 153620, Gene2Phenotype
MIF is in 2 panels

1 review

Rebecca Foulger (Genomics England curator)

Comment on list classification: Upgraded rating from Red to Amber. Several animal models showing that MIF is expressed during viral infection (PMIDs:30944975, 31292300, 17909632) plus study of MIF polymorphisms and West Nile virus infection in PMID:26638028.
Created: 21 May 2020, 4:36 p.m. | Last Modified: 21 May 2020, 4:36 p.m.
Panel Version: 0.277
PMID:31292300. Smith et al., 2019 showed that, during influenza viral infection, Mif-deficient mice have less inflammation, viral load, and mortality compared with WT control mice.
Created: 21 May 2020, 4:33 p.m. | Last Modified: 21 May 2020, 4:33 p.m.
Panel Version: 0.276
PMID:26638028. Das et al., 2016 examined functional polymorphisms in MIF in a cohort of 454 North American patients with neuroinvasive West Nile virus (WNV) disease and found patients homozygous for high-expression MIF allels to be >20 fold more likely to have WNV encephalitis.
Created: 21 May 2020, 4:33 p.m. | Last Modified: 21 May 2020, 4:33 p.m.
Panel Version: 0.276
PMID:30944975. de Souza et al 2019 demonstrate in mice that MIF is expressed during RSV infection and controls the release of pro-inflammatory cytokines from macrophages in an in vitro model.
Created: 21 May 2020, 4:31 p.m. | Last Modified: 21 May 2020, 4:36 p.m.
Panel Version: 0.277
Comment on list classification: MIF was identified through an OMIM search for potential viral susceptibility genes. Based on initial triage by Illumina (Tier 5 grouping), added to panel initially as Red awaiting further curation. Notes from Julie Taylor and Alison Coffey (Illumina): Arjona et al. (2007) found that blocking Mif action in mice either by antibody, small molecule antagonist, or gene deletion increased resistance to West Nile Virus lethality.
Created: 21 May 2020, 4:25 p.m. | Last Modified: 21 May 2020, 4:28 p.m.
Panel Version: 0.276
PMID:17909632. Arjona et al. (2007) showed that patients with acute West Nile virus (WNV) infection had increased levels of MIF in plasma and cerebrospinal fluid. Studies in mice showed that MIF is involved in WNV pathogenesis.
Sources: Other
Created: 21 May 2020, 4:24 p.m.

Mode of inheritance
Unknown

Publications

Details

Mode of Inheritance
Unknown
Sources
Phenotypes
  • {Rheumatoid arthritis, systemic juvenile, susceptibility to}, 604302
OMIM
153620
Clinvar variants
Variants in MIF
Penetrance
None
Publications
Panels with this gene

History Filter Activity

21 May 2020, Gel status: 2

Entity classified by Genomics England curator

Rebecca Foulger (Genomics England curator)

Gene: mif has been classified as Amber List (Moderate Evidence).

21 May 2020, Gel status: 1

Entity classified by Genomics England curator

Rebecca Foulger (Genomics England curator)

Gene: mif has been classified as Red List (Low Evidence).

21 May 2020, Gel status: 1

Set Phenotypes

Rebecca Foulger (Genomics England curator)

Phenotypes for gene: MIF were changed from to {Rheumatoid arthritis, systemic juvenile, susceptibility to}, 604302

21 May 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications

Rebecca Foulger (Genomics England curator)

gene: MIF was added gene: MIF was added to COVID-19 research. Sources: Other Mode of inheritance for gene: MIF was set to Unknown Publications for gene: MIF were set to 17909632