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COVID-19 research

Gene: IRF5

Green List (high evidence)

IRF5 (interferon regulatory factor 5)
EnsemblGeneIds (GRCh38): ENSG00000128604
EnsemblGeneIds (GRCh37): ENSG00000128604
OMIM: 607218, Gene2Phenotype
IRF5 is in 2 panels

1 review

Rebecca Foulger (Genomics England curator)

Comment on list classification: Green rating suggested after initial triage by Illumina curation team. Kept rating as Green following literature review: PMID:29375210 demonstrate that polymorphisms in IRF5 can affect viral disease progression. Functional studies and animal models (fish and mice) show that IRF5 is required for antiviral immunity. Therefore on balance, kept rating as Green.
Created: 28 May 2020, 8:46 p.m. | Last Modified: 28 May 2020, 8:46 p.m.
Panel Version: 0.374
PMID:30457675. Chow et al., 2019 examined IRF5-dependent gene expression and found that loss of IRF5 in mice resulted in modest and subtle changes in the expression of West Nile Virus (WNV)-regulated genes.
15320958
Created: 28 May 2020, 8:43 p.m. | Last Modified: 28 May 2020, 8:43 p.m.
Panel Version: 0.373
PMID:21240265. Krausgruber et al., 2011 state that polymorphisms in IRF5 that lead to higher mRNA expression are associated with many autoimmune diseases. Global gene expression analysis demonstrated that exogenous IRF5 upregulated or downregulated expression of established phenotypic markers of M1 or M2 macrophages, respectively, defining a role for IRF5 as a transcriptional repressor.
Created: 28 May 2020, 8:43 p.m. | Last Modified: 28 May 2020, 8:43 p.m.
Panel Version: 0.373
PMID:29079574. Cevik et al., 2017 identify IRF5 as an important suppressor of HCV replication and HCC pathogenesis.
Created: 28 May 2020, 8:43 p.m. | Last Modified: 28 May 2020, 8:43 p.m.
Panel Version: 0.373
PMID:29375210. Sy et al., 2018 investigated possible effects of IRF5 polymorphisms in the 3' UTR region of the IFR5 locus on susceptibility to hepatitis B virus (HBV) infection and liver disease outcomes. Comparing patients and controls, no significant association was observed in viral load for the four IFR5 variants studied, but alleles rs13242262T and rs10488630G contributed to an increased risk of liver cirrhosis. The process of liver cirrhosis in HBV infection is a results of the interplay between viral factors and host immune responses suggesting that IRF5 haplotypes appear to influence the outcome of HBV infection.
Created: 28 May 2020, 8:43 p.m. | Last Modified: 28 May 2020, 8:43 p.m.
Panel Version: 0.373
PMID:32075938. Forbester et al., 2020 use human-induced pluripotent stem cells (hIPSCs) with biallelic mutations in IRF5, and showed that IRF5 deficiency corresponded with reduced influenza virus-induced inflammatory cytokine production.
Created: 28 May 2020, 8:43 p.m. | Last Modified: 28 May 2020, 8:43 p.m.
Panel Version: 0.373
PMID:17360658. Yanai et al., 2007. Mouse model: authors show that IRF5 is critical for antiviral immunity by showing that Irf5(-/-) mice are highly vulnerable to viral infections.
Created: 28 May 2020, 8:43 p.m. | Last Modified: 28 May 2020, 8:43 p.m.
Panel Version: 0.373
Identified through an OMIM search for potential viral susceptibility genes, and subsequently triaged/reviewed by Illumina curation team.
Created: 28 May 2020, 3:49 p.m. | Last Modified: 28 May 2020, 3:49 p.m.
Panel Version: 0.352

Details

Mode of Inheritance
Unknown
Sources
OMIM
607218
Clinvar variants
Variants in IRF5
Penetrance
None
Publications
Panels with this gene

History Filter Activity

28 May 2020, Gel status: 3

Entity classified by Genomics England curator

Rebecca Foulger (Genomics England curator)

Gene: irf5 has been classified as Green List (High Evidence).

28 May 2020, Gel status: 3

Set publications

Rebecca Foulger (Genomics England curator)

Publications for gene: IRF5 were set to 17360658; 32075938; 29375210; 29079574; 1240265; 30457675

28 May 2020, Gel status: 3

Set publications

Rebecca Foulger (Genomics England curator)

Publications for gene: IRF5 were set to

28 May 2020, Gel status: 3

Entity classified by Genomics England curator

Rebecca Foulger (Genomics England curator)

Gene: irf5 has been classified as Green List (High Evidence).

28 May 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance

Rebecca Foulger (Genomics England curator)

gene: IRF5 was added gene: IRF5 was added to COVID-19 research. Sources: Expert list Mode of inheritance for gene: IRF5 was set to Unknown