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COVID-19 research

Gene: MUC5B

Red List (low evidence)

MUC5B (mucin 5B, oligomeric mucus/gel-forming)
EnsemblGeneIds (GRCh38): ENSG00000117983
EnsemblGeneIds (GRCh37): ENSG00000117983
OMIM: 600770, Gene2Phenotype
MUC5B is in 3 panels

1 review

Eleanor Williams (Genomics England Curator)

Red List (low evidence)

Preprint: van Moorsel et al The mucin MUC5B is an important component of the innate immune response and expression levels are associated with the MUC5B promoter polymorphism, rs35705950. They compared patients with severe COVID-19 to controls and found the MUC5B rs35705950 promoter polymorphism associates with COVID-19. The risk allele (T) for idiopathic pulmonary fibrosis (IPF) is protective against the development of severe COVID-19 disease.
Sources: Literature
Created: 22 May 2020, 9:44 a.m.

Mode of inheritance




Mode of Inheritance
  • Literature
Clinvar variants
Variants in MUC5B
Panels with this gene

History Filter Activity

22 May 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance

Eleanor Williams (Genomics England Curator)

gene: MUC5B was added gene: MUC5B was added to COVID-19 research. Sources: Literature Mode of inheritance for gene: MUC5B was set to Unknown Review for gene: MUC5B was set to RED