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STRs in panel
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COVID-19 research

Gene: MUC5B

Red List (low evidence)

MUC5B (mucin 5B, oligomeric mucus/gel-forming)
EnsemblGeneIds (GRCh38): ENSG00000117983
EnsemblGeneIds (GRCh37): ENSG00000117983
OMIM: 600770, Gene2Phenotype
MUC5B is in 2 panels

1 review

Eleanor Williams (Genomics England Curator)

Red List (low evidence)

Preprint: van Moorsel et al https://doi.org/10.1101/2020.05.12.20099333 The mucin MUC5B is an important component of the innate immune response and expression levels are associated with the MUC5B promoter polymorphism, rs35705950. They compared patients with severe COVID-19 to controls and found the MUC5B rs35705950 promoter polymorphism associates with COVID-19. The risk allele (T) for idiopathic pulmonary fibrosis (IPF) is protective against the development of severe COVID-19 disease.
Sources: Literature
Created: 22 May 2020, 9:44 a.m.

Mode of inheritance
Unknown

Publications

  • https://doi.org/10.1101/2020.05.12.20099333

Details

Mode of Inheritance
Unknown
Sources
  • Literature
OMIM
600770
Clinvar variants
Variants in MUC5B
Penetrance
None
Panels with this gene

History Filter Activity

22 May 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance

Eleanor Williams (Genomics England Curator)

gene: MUC5B was added gene: MUC5B was added to COVID-19 research. Sources: Literature Mode of inheritance for gene: MUC5B was set to Unknown Review for gene: MUC5B was set to RED