COVID-19 research
Gene: POLR3F
May contribute to viral susceptibility in a non-Mendelian wayCreated: 1 May 2020, 12:17 p.m. | Last Modified: 1 May 2020, 12:17 p.m.
Panel Version: 0.171
IUIS: categorised under the Predisposition to severe viral infection section. Inheritance: AD. Affects Leukocytes and other cells and causes impaired viral recognition and IFN induction in response to VZVor poly I:C. The associated features is severe VZV infection.Created: 15 Apr 2020, 12:09 p.m. | Last Modified: 15 Apr 2020, 12:09 p.m.
Panel Version: 0.103
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Phenotypes
Defects in intrinsic and innate immunity; Predisposition to severe viral infection; RNA polymerase III deficiency
Publications
Added POLR3F to panel based on presence on VCGS 'Susceptibility to Viral Infections' panel V0.22: https://panelapp.agha.umccr.org/panels/237/Created: 9 Apr 2020, 4:17 p.m. | Last Modified: 9 Apr 2020, 4:17 p.m.
Panel Version: 0.76
Publications for gene: POLR3F were set to 30211253
Source Expert Review Green was added to POLR3F. Source IUIS Classification December 2019 was added to POLR3F. Added phenotypes RNA polymerase III deficiency; Defects in intrinsic and innate immunity; Predisposition to severe viral infection for gene: POLR3F Rating Changed from Red List (low evidence) to Green List (high evidence)
gene: POLR3F was added gene: POLR3F was added to Viral susceptibility. Sources: Expert Review Red,Victorian Clinical Genetics Services,Expert list Mode of inheritance for gene: POLR3F was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Publications for gene: POLR3F were set to 30211253 Phenotypes for gene: POLR3F were set to Severe VZV infection