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STRs in panel
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COVID-19 research

Gene: SCN5A

Red List (low evidence)

SCN5A (sodium voltage-gated channel alpha subunit 5)
EnsemblGeneIds (GRCh38): ENSG00000183873
EnsemblGeneIds (GRCh37): ENSG00000183873
OMIM: 600163, Gene2Phenotype
SCN5A is in 12 panels

2 reviews

Eleanor Williams (Genomics England Curator)

PMID: 32380288 Giudicessi et al 2020 - discuss the potential of p.Ser1103Tyr-SCN5A to exacerbate outcome-related health disparities in the COVID-19 pandemic.

Keeping red for now, as this paper is speculation - no real data.
Created: 13 May 2020, 4:02 p.m. | Last Modified: 13 May 2020, 4:10 p.m.
Panel Version: 0.226

Publications

Sarah Leigh (Genomics England Curator)

Red List (low evidence)

SCN5A initiates signaling in an innate immune pathway relevant to antiviral host defense and that SCN5A is a pathogen sensor (PMID 25368329)
Created: 4 May 2020, 3:17 p.m. | Last Modified: 4 May 2020, 3:17 p.m.
Panel Version: 0.176

Publications

History Filter Activity

13 May 2020, Gel status: 1

Set publications

Eleanor Williams (Genomics England Curator)

Publications for gene: SCN5A were set to

21 Apr 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance

Sarah Leigh (Genomics England Curator)

gene: SCN5A was added gene: SCN5A was added to Viral susceptibility. Sources: OMIM Mode of inheritance for gene: SCN5A was set to