SCN5A

sodium voltage-gated channel alpha subunit 5
OMIM: 600163, Gene2Phenotype

13 panels

Panel	Reviews	Mode of inheritance	Details
Filter panels 13 panels
Amber SCN5A in Idiopathic ventricular fibrillation Level 3: Cardiac arrhythmia Level 2: Cardiovascular disorders Version 1.2	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources Expert Review Amber Illumina TruGenome Clinical Sequencing Services Radboud University Medical Center, Nijmegen Phenotypes Ventricular fibrillation, familial, 1, 603829 Ventricular fibrillation, familial, 1, Paroxysmal Familial Ventricular Fibrillation
No list SCN5A in Fetal hydrops Level 3: Fetal disorders Level 2: Dysmorphic and congenital abnormality syndromes Version 1.64	review	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Literature Phenotypes Nonimmune hydrops fetalis
Red SCN5A in COVID-19 research Level 2: Viral research Version 1.141	review	Not set	Sources OMIM
Green SCN5A in Progressive cardiac conduction disease Version 2.6 Latest signed off version: v2.2 (22 Mar 2023) Component of the following Super Panels: Sudden unexplained death or survivors of a cardiac event	review	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Green South West GLH London South GLH Wessex and West Midlands GLH Expert list Phenotypes Heart block, progressive, OMIM:113900 Heart block, progressive, type IA, OMIM:113900
Amber SCN5A in Short QT syndrome Version 3.10 Latest signed off version: v3.1 (22 Mar 2023) Component of the following Super Panels: Cardiac arrhythmias Sudden unexplained death or survivors of a cardiac event	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources South West GLH North West GLH Expert Review Amber Brugada syndrome (Version 1.7) Long QT syndrome (Version 1.5) Emory Genetics Laboratory Literature Phenotypes Ventricular fibrillation, familial, 1 (603829) Brugada syndrome 1 (601144) {Sudden infant death syndrome, susceptibility to} (272120) Brugada syndrome 1 601144 Heart block, progressive, type IA (113900) Heart block, nonprogressive (113900) Sick sinus syndrome 1 (608567) Long QT syndrome-3 (603830) Cardiomyopathy, dilated, 1E (601154) Atrial fibrillation, familial, 10 (614022) Tags watchlist
Red SCN5A in Arrhythmogenic right ventricular cardiomyopathy Level 3: Cardiomyopathy Level 2: Cardiovascular disorders Version 3.9 Latest signed off version: v3.5 (22 Mar 2023) Component of the following Super Panels: Sudden unexplained death or survivors of a cardiac event	review	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources South West GLH London South GLH Literature Phenotypes Arrhythmogenic right ventricular cardiomyopathy Long QT syndrome Brugada syndrome Dilated cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy
Green SCN5A in Long QT syndrome Level 3: Cardiac arrhythmia Level 2: Cardiovascular disorders Version 3.7 Latest signed off version: v3.1 (22 Mar 2023) Component of the following Super Panels: Cardiac arrhythmias Sudden unexplained death or survivors of a cardiac event Unexplained death in infancy and sudden unexplained death in childhood	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources Expert Review Green Eligibility statement prior genetic testing Expert list Emory Genetics Laboratory Illumina TruGenome Clinical Sequencing Services Radboud University Medical Center, Nijmegen UKGTN Phenotypes Ventricular fibrillation, familial, 1 (603829) Brugada syndrome 1 (601144) Heart block, nonprogressive (113900) Heart block, progressive, type IA (113900) {Sudden infant death syndrome, susceptibility to} (272120) Sick sinus syndrome 1 (608567) Long QT syndrome-3 Long QT syndrome-3 (603830) Cardiomyopathy, dilated, 1E (601154) Atrial fibrillation, familial, 10 (614022)
Green SCN5A in Dilated Cardiomyopathy and conduction defects Level 3: Cardiomyopathy Level 2: Cardiovascular disorders Version 1.85	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources South West GLH London South GLH North West GLH Expert Review Green Expert list Emory Genetics Laboratory Radboud University Medical Center, Nijmegen Illumina TruGenome Clinical Sequencing Services Phenotypes Cardiomyopathy, dilated, 1E
Green SCN5A in Brugada syndrome and cardiac sodium channel disease Level 3: Cardiac arrhythmia Level 2: Cardiovascular disorders Version 3.8 Latest signed off version: v3.2 (22 Mar 2023) Component of the following Super Panels: Cardiac arrhythmias Sudden unexplained death or survivors of a cardiac event	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources South West GLH London South GLH North West GLH Expert Review Green Eligibility statement prior genetic testing Expert list Emory Genetics Laboratory Radboud University Medical Center, Nijmegen Illumina TruGenome Clinical Sequencing Services UKGTN Phenotypes Brugada syndrome 1, 601144 Brugada syndrome 1, MONDO:0011001
Green SCN5A in Dilated and arrhythmogenic cardiomyopathy Level 3: Cardiomyopathy Level 2: Cardiovascular disorders Version 2.22 Latest signed off version: v2.8 (22 Mar 2023) Component of the following Super Panels: Sudden unexplained death or survivors of a cardiac event	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources Expert Review Green South West GLH Radboud University Medical Center, Nijmegen Illumina TruGenome Clinical Sequencing Services London South GLH North West GLH Expert list Emory Genetics Laboratory South West GLH London South GLH North West GLH Phenotypes Cardiomyopathy, dilated, 1E
Red SCN5A in Hereditary neuropathy Level 3: Motor and Sensory Disorders of the PNS Level 2: Neurology and neurodevelopmental disorders Version 1.477	review	Not set	Sources NHS GMS South West GLH Emory Genetics Laboratory Phenotypes Cardiomyopathy
Green SCN5A in Paediatric or syndromic cardiomyopathy Version 3.46 Latest signed off version: v3.0 (22 Mar 2023) Component of the following Super Panels: Unexplained death in infancy and sudden unexplained death in childhood	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources NHS GMS South West GLH Expert Review Green Phenotypes Dilated cardiomyopathy Long QT syndrome Brugada syndrome Cardiomyopathy, dilated, 1E Arrhythmogenic right ventricular cardiomyopathy
Red SCN5A in Hereditary neuropathy or pain disorder Version 3.94 Latest signed off version: v3.24 (15 May 2023)	review	Not set	Sources NHS GMS South West GLH Emory Genetics Laboratory NHS GMS South West GLH Phenotypes Cardiomyopathy