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COVID-19 research

Gene: ELF4

Red List (low evidence)

ELF4 (E74 like ETS transcription factor 4)
EnsemblGeneIds (GRCh38): ENSG00000102034
EnsemblGeneIds (GRCh37): ENSG00000102034
OMIM: 300775, Gene2Phenotype
ELF4 is in 2 panels

5 reviews

Rebecca Foulger (Genomics England curator)

Some evidence that ELF4 is involved in the anti-viral innate immune response, but no genetic data. Therefore keeping rating as Red.
Created: 16 Apr 2020, 1:17 p.m. | Last Modified: 16 Apr 2020, 1:17 p.m.
Panel Version: 0.106
PMID:30089112 (Du et al., 2018) show that during the antiviral response, miR-221 was induced through ELF4 binding to its promoter (mice cells, recombinant human ELF4).
Created: 16 Apr 2020, 1:01 p.m. | Last Modified: 16 Apr 2020, 1:05 p.m.
Panel Version: 0.106
PMID:24185615. You et al. (2013) observed enhanced susceptibility to West Nile Virus in mice with a loss-of-function mutation in Sting (TMEM173). ELF4 was identified as an interacting partner of STING. Viral infection or stimulation with IFN induced ELF4 expression, which reduced viral replication, in human cells. Infection of Elf4 -/- mice with WNV resulted in enhanced viral burden and lethality. The authors concluded that ELF4 activates the innate immune response by promoting the production of type I interferons.
Created: 16 Apr 2020, 1:01 p.m. | Last Modified: 16 Apr 2020, 1:01 p.m.
Panel Version: 0.106

Tracy Briggs (Manchester Genomic Medicine Centre)

Red List (low evidence)

Sophie Hambleton (Newcastle University)

Red List (low evidence)

Peter Arkwright (Royal Manchester Foundation Trust)

Red List (low evidence)

Sarah Leigh (Genomics England Curator)

Comment when marking as ready: Three negative expert reviews. No phenotype in OMIM. No disease associated in Gen2Phen.
Created: 11 May 2016, 10:41 a.m.
Comment on mode of pathogenicity: unknown
Created: 10 May 2016, 11:01 a.m.

Details

Mode of Inheritance
Unknown
Sources
Phenotypes
  • X-linked hypogammaglobulinemia with isolated growth hormone deficiency
OMIM
300775
Clinvar variants
Variants in ELF4
Penetrance
None
Publications
Panels with this gene

History Filter Activity

1 Apr 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Ellen McDonagh (Genomics England Curator)

gene: ELF4 was added gene: ELF4 was added to Viral susceptibility. Sources: Expert Review Red,A- or hypo-gammaglobulinaemia v1.25 Mode of inheritance for gene: ELF4 was set to Unknown Publications for gene: ELF4 were set to 16264330 Phenotypes for gene: ELF4 were set to X-linked hypogammaglobulinemia with isolated growth hormone deficiency