COVID-19 research
Gene: ELF4Some evidence that ELF4 is involved in the anti-viral innate immune response, but no genetic data. Therefore keeping rating as Red.Created: 16 Apr 2020, 1:17 p.m. | Last Modified: 16 Apr 2020, 1:17 p.m.
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PMID:30089112 (Du et al., 2018) show that during the antiviral response, miR-221 was induced through ELF4 binding to its promoter (mice cells, recombinant human ELF4).Created: 16 Apr 2020, 1:01 p.m. | Last Modified: 16 Apr 2020, 1:05 p.m.
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PMID:24185615. You et al. (2013) observed enhanced susceptibility to West Nile Virus in mice with a loss-of-function mutation in Sting (TMEM173). ELF4 was identified as an interacting partner of STING. Viral infection or stimulation with IFN induced ELF4 expression, which reduced viral replication, in human cells. Infection of Elf4 -/- mice with WNV resulted in enhanced viral burden and lethality. The authors concluded that ELF4 activates the innate immune response by promoting the production of type I interferons.Created: 16 Apr 2020, 1:01 p.m. | Last Modified: 16 Apr 2020, 1:01 p.m.
Panel Version: 0.106
Comment when marking as ready: Three negative expert reviews. No phenotype in OMIM. No disease associated in Gen2Phen.Created: 11 May 2016, 10:41 a.m.
Comment on mode of pathogenicity: unknownCreated: 10 May 2016, 11:01 a.m.
gene: ELF4 was added gene: ELF4 was added to Viral susceptibility. Sources: Expert Review Red,A- or hypo-gammaglobulinaemia v1.25 Mode of inheritance for gene: ELF4 was set to Unknown Publications for gene: ELF4 were set to 16264330 Phenotypes for gene: ELF4 were set to X-linked hypogammaglobulinemia with isolated growth hormone deficiency