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COVID-19 research


Red List (low evidence)

SELPLG (selectin P ligand)
EnsemblGeneIds (GRCh38): ENSG00000110876
EnsemblGeneIds (GRCh37): ENSG00000110876
OMIM: 600738, Gene2Phenotype
SELPLG is in 2 panels

1 review

Sarah Leigh (Genomics England Curator)

Red List (low evidence)

PMID: 30833724 identifies SELPLG (refered to as PSGL1 in the literature) as an HIV restriction factor, SELPLG is induced by interferon-γ in activated CD4+ T cells to inhibit HIV-1 reverse transcription and potently block viral infectivity by incorporating in progeny virions.
Preprint report that virion incorporation of SELPLG on SARS-CoV and SARS-CoV-2 pseudovirions blocks S protein-mediated virus attachment and infection of target cells, Suggesting that SELPLG-imprinted non-infectious viral particles could serve as a live attenuated vaccine for SARS-CoV-2 infection.
Created: 12 May 2020, 8:19 a.m. | Last Modified: 12 May 2020, 8:19 a.m.
Panel Version: 0.207
In PMID 19543284 SELPLG (refered to as PSGL1 in the literature) is a receptor for 5 of 8 the Enterovirus-71 (EV71) strains. EV71 interaction and viral replication could be inhibited by monoclonal antibodies to SELPLG. The authors concluded that SELPLG-positive leukocytes are involved in the cell tropism and pathogenesis of hand, foot and mouth disease and other EV71-mediated diseases.
Sources: Literature
Created: 12 May 2020, 8:14 a.m.

Mode of inheritance



Mode of Inheritance
  • Literature
Clinvar variants
Variants in SELPLG
Panels with this gene

History Filter Activity

12 May 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications

Sarah Leigh (Genomics England Curator)

gene: SELPLG was added gene: SELPLG was added to Viral susceptibility. Sources: Literature Mode of inheritance for gene: SELPLG was set to Unknown Publications for gene: SELPLG were set to 19543284; 30833724; Review for gene: SELPLG was set to RED