Description
This gene panel is currently in progress. We encourage experts to review the genes to help establish a list of 'Green' (high level of evidence) genes for resistance to viral infection. Missing genes can be added to the panel by Reviewers, or please submit a list to [email protected]. 

This is a gene panel for research use. Therefore the evidence level required for a gene to be Green may be more inclusive than our guidelines for monogenic diseases.
Panel Activity

4 reviewers

  • Sarah Leigh (Genomics England Curator)

    Group: Other
    Workplace: Other

  • Rebecca Foulger (Genomics England curator)

    Group: Other
    Workplace: Other

  • Eleanor Williams (Genomics England Curator)

    Group: Other
    Workplace: Other

  • Ivone Leong (Genomics England Curator)

    Group: Other
    Workplace: Other

24 Entities

23 reviewed, 7 green

List Entity Reviews Mode of inheritance Details
24 Entitiess
Green Green List (high evidence)
CCR5
1 review
 BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal
Sources
  • Expert list
  • Expert Review Green
  • Literature
Phenotypes
  • {Hepatitis C virus, resistance to}, 609532
  • {HIV infection, susceptibility/resistance to}
Tags
Green Green List (high evidence)
CXCR1
1 review
 Unknown
Sources
  • Expert Review Green
  • OMIM
Phenotypes
  • {AIDS, slow progression to} 609423
Tags
Green Green List (high evidence)
FUT2
1 review
 BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert list
  • Expert Review Green
  • Literature
Phenotypes
  • {Norwalk virus infection, resistance to}
Tags
Green Green List (high evidence)
KIR3DL1
1 review
 Unknown
Sources
  • Expert Review Green
  • OMIM
Phenotypes
  • {AIDS, delayed/rapid progression to} 609423
Tags
Green Green List (high evidence)
LDLR
2 reviews
1 green 		MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Green
  • Literature
Phenotypes
  • Hypercholesterolemia, familial, 1 143890
  • LDL cholesterol level QTL2 143890
Tags
Green Green List (high evidence)
TLR3
1 review
 Unknown
Sources
  • Expert Review Green
  • OMIM
Phenotypes
  • {HIV1 infection, resistance to} 609423
Tags
Green Green List (high evidence)
TNF
2 reviews
 Unknown
Sources
  • Expert Review Green
  • OMIM
Tags
Amber Amber List (moderate evidence)
CXCL12
1 review
 Not set
Sources
  • Expert Review Amber
  • OMIM
Phenotypes
  • {AIDS, resistance to} 609423
Tags
Amber Amber List (moderate evidence)
DDX58
2 reviews
 Unknown
Sources
  • Expert Review Amber
  • Literature
Tags
  • new-gene-name
Amber Amber List (moderate evidence)
MX1
2 reviews
 Unknown
Sources
  • Expert Review Amber
  • Literature
Tags
Red Red List (low evidence)
ACKR1
1 review
 Unknown
Sources
  • Expert list
  • Expert Review Red
  • Literature
Phenotypes
  • {Malaria, vivax, protection against}, 611162
Tags
Red Red List (low evidence)
CCL11
1 review
1 red 		Unknown
Sources
  • Expert Review Red
  • Other
Phenotypes
  • {HIV1, resistance to} 609423
Tags
Red Red List (low evidence)
CCL2
1 review
 Not set
Sources
  • Expert Review Red
  • OMIM
Phenotypes
  • {HIV-1, resistance to} 609423
Tags
Red Red List (low evidence)
CCL3
0 reviews
 Not set
Sources
  • OMIM
Phenotypes
  • {HIV infection, resistance to} 609423
Tags
Red Red List (low evidence)
CD209
2 reviews
 Not set
Sources
  • OMIM
Phenotypes
  • {Dengue fever, protection against} 614371
Tags
Red Red List (low evidence)
CLEC4M
1 review
 Unknown
Sources
  • Expert Review Red
  • Other
Phenotypes
  • SARS infection, protection against, 605872
Tags
Red Red List (low evidence)
DPP4
1 review
1 red 		Unknown
Sources
  • Literature
Tags
Red Red List (low evidence)
HLA-B
1 review
 Unknown
Sources
  • Literature
Phenotypes
  • immunity to COVID-19
Tags
Red Red List (low evidence)
HLA-C
1 review
 Not set
Sources
  • OMIM
Phenotypes
  • {HIV-1 viremia, susceptibility to} 609423
Tags
Red Red List (low evidence)
HLA-DQB1
1 review
 Not set
Sources
  • OMIM
Tags
Red Red List (low evidence)
IFNG
1 review
 Unknown
Sources
  • OMIM
Phenotypes
  • {AIDS, rapid progression to} 609423
  • {Hepatitis C virus, response to therapy of}, 609532
Tags
Red Red List (low evidence)
IL22
1 review
 Unknown
Sources
  • Literature
Phenotypes
  • resistance to lethal West Nile virus
Tags
Red Red List (low evidence)
IL4R
2 reviews
 BIALLELIC, autosomal or pseudoautosomal
Sources
  • OMIM
Phenotypes
  • {AIDS, slow progression to} 609423
Tags
Red Red List (low evidence)
SELPLG
1 review
1 red 		Unknown
Sources
  • Literature
Tags

Downloads

Download lists

Download Version