This Panel is marked as Internal
Viral resistance
Gene: DPP4
DPP4 (dipeptidyl peptidase 4)
EnsemblGeneIds (GRCh38): ENSG00000197635
EnsemblGeneIds (GRCh37): ENSG00000197635
OMIM: 102720, Gene2Phenotype
DPP4 is in 1 panel
EnsemblGeneIds (GRCh38): ENSG00000197635
EnsemblGeneIds (GRCh37): ENSG00000197635
OMIM: 102720, Gene2Phenotype
DPP4 is in 1 panel
1 review
Eleanor Williams (Genomics England Curator)
PMID: 31964246 - Kleine-Weber et al 2020- looked at naturally-occurring polymorphisms in DPP4 from public databases, that alter amino acid residues required for MERS-CoV S binding to see if they influence cellular entry of MERS-CoV. Four polymorphisms (K267E, K267N, A291P and Δ346-348) strongly reduced binding of MERS-CoV S to DPP4 and S protein-driven host cell entry, as determined using soluble S protein and S protein bearing rhabdoviral vectors, respectively. Two polymorphisms (K267E and A291P) were analyzed in the context of authentic MERS-CoV and were found to attenuate viral replication.
Sources: LiteratureCreated: 13 May 2020, 10:02 p.m.
Mode of inheritance
Unknown
Publications
Details
- Mode of Inheritance
- Unknown
- Sources
-
- Literature
- OMIM
- 102720
- Clinvar variants
- Variants in DPP4
- Penetrance
- None
- Publications
- Panels with this gene
History Filter Activity
13 May 2020, Gel status: 1
Created, Added New Source, Set mode of inheritance, Set publications
Eleanor Williams (Genomics England Curator)gene: DPP4 was added gene: DPP4 was added to Viral resistance. Sources: Literature Mode of inheritance for gene: DPP4 was set to Unknown Publications for gene: DPP4 were set to 31964246 Review for gene: DPP4 was set to RED