Viral resistance
Gene: CLEC4MComment on list classification: Although a 2006 study (PMID:16369534) finds an association between CLEC4M variable number tandem repeat polymorphisms, and protection against SARS viral infection, subsequent studies do not support this association (PMIDs 17534354, 17534355, 18697825). Therefore rated as Red awaiting further evidence.Created: 2 Jun 2020, 4:53 p.m. | Last Modified: 2 Jun 2020, 8:07 p.m.
Panel Version: 0.59
PMID:18697825 (Li et al., 2008) suggested that the previously reported association with polymorphisms in the CLEC4M gene may be due to population stratification.Created: 2 Jun 2020, 4:51 p.m. | Last Modified: 2 Jun 2020, 4:54 p.m.
Panel Version: 0.59
In contrast to Chan et al., 2006 (PMID:16369534), Tang et al. (2007, PMID:17534354) found no support for an association between CLEC4M homozygosity and protection against SARS. Zhi et al. (2007, PMID:17534355) also found that the protective effect of CLEC4M homozygosity could not be replicated. The authors from the original study (PMID:16369534) suggested that controls were not matched in these subsequent studies.Created: 2 Jun 2020, 4:50 p.m. | Last Modified: 2 Jun 2020, 4:54 p.m.
Panel Version: 0.59
Added to panel based on OMIM search. CLEC4M has considerable polymorphism in the tandem repeat domain of exon 4 (3 to 9 repeats of a 69-basepair segment, with 7 repeats being predominant in the general population). Chan et al. (2006, PMID:16369534) performed a genetic risk association study and found that individuals homozygous for CLEC4M tandem repeats are less susceptible to SARS infection. Compared with cells heterozygous for CLEC4M, cells homozygous for CLEC4M showed higher binding capacity for SARS-CoV, higher proteasome-dependent viral degradation, and a lower capacity for trans infection. Thus, homozygosity for CLEC4M tandem repeats plays a protective role during SARS infection.
Sources: OtherCreated: 2 Jun 2020, 4:47 p.m. | Last Modified: 2 Jun 2020, 8:04 p.m.
Panel Version: 0.59
Mode of inheritance
Unknown
Phenotypes
SARS infection, protection against, 605872
Publications
Gene: clec4m has been classified as Red List (Low Evidence).
Publications for gene: CLEC4M were set to 16369534
gene: CLEC4M was added gene: CLEC4M was added to Viral resistance. Sources: Other Mode of inheritance for gene: CLEC4M was set to Unknown Publications for gene: CLEC4M were set to 16369534 Phenotypes for gene: CLEC4M were set to SARS infection, protection against, 605872