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Viral resistance v0.59 CLEC4M Rebecca Foulger changed review comment from: Comment on list classification: Although a 2006 study (PMID:16369534) finds an association between CLEC4M variable number tandem repeat polymoprhisms, and protection against SARS viral infection, subsequent studies do not support this association (PMIDs 17534354, 17534355, 18697825). Therefore rated as Red awaiting further evidence.; to: Comment on list classification: Although a 2006 study (PMID:16369534) finds an association between CLEC4M variable number tandem repeat polymorphisms, and protection against SARS viral infection, subsequent studies do not support this association (PMIDs 17534354, 17534355, 18697825). Therefore rated as Red awaiting further evidence.
Viral resistance v0.59 CLEC4M Rebecca Foulger changed review comment from: Added to panel based on OMIM search. CLEC4M has considerable polymorphism in the tandem repeat domain of exon 4 (3 to 9 repeats of a 69-basepair segment, with 7 repeats being predominant in the general population). Chan et al. (2006, PMID:16369534) performed a genetic risk association study and found that individuals homozygous for CLEC4M tandem repeats are less susceptible to SARS infection. CLEC4M was expressed in both non-SARS and SARS-CoV-infected lung. Compared with cells heterozygous for CLEC4M, cells homozygous for CLEC4M showed higher binding capacity for SARS-CoV, higher proteasome-dependent viral degradation, and a lower capacity for trans infection. Thus, homozygosity for CLEC4M plays a protective role during SARS infection.
Sources: Other; to: Added to panel based on OMIM search. CLEC4M has considerable polymorphism in the tandem repeat domain of exon 4 (3 to 9 repeats of a 69-basepair segment, with 7 repeats being predominant in the general population). Chan et al. (2006, PMID:16369534) performed a genetic risk association study and found that individuals homozygous for CLEC4M tandem repeats are less susceptible to SARS infection. Compared with cells heterozygous for CLEC4M, cells homozygous for CLEC4M showed higher binding capacity for SARS-CoV, higher proteasome-dependent viral degradation, and a lower capacity for trans infection. Thus, homozygosity for CLEC4M tandem repeats plays a protective role during SARS infection.
Sources: Other
Viral resistance v0.59 CLEC4M Rebecca Foulger changed review comment from: Comment on list classification: Although a 2006 study (PMID:16369534) finds an association between tandem repeats within CLEC4M, and protection against SARS viral infection, subsequent studies do not support this association (PMIDs 17534354, 17534355, 18697825). Therefore rated as Red awaiting further evidence.; to: Comment on list classification: Although a 2006 study (PMID:16369534) finds an association between CLEC4M variable number tandem repeat polymoprhisms, and protection against SARS viral infection, subsequent studies do not support this association (PMIDs 17534354, 17534355, 18697825). Therefore rated as Red awaiting further evidence.
Viral resistance v0.59 CLEC4M Rebecca Foulger changed review comment from: Comment on list classification: Although a 2006 study finds an association between tandem repeats within CLEC4M , and protection against SARS viral infection, subsequent studies do not support this association. Therefore rated as Red awaiting further evidence.; to: Comment on list classification: Although a 2006 study (PMID:16369534) finds an association between tandem repeats within CLEC4M, and protection against SARS viral infection, subsequent studies do not support this association (PMIDs 17534354, 17534355, 18697825). Therefore rated as Red awaiting further evidence.
Viral resistance v0.59 CLEC4M Rebecca Foulger changed review comment from: PMID:18697825 (Li et al., 2008) suggested that the previously reported association with polymorphisms in the CLEC4M neck region may be due to population stratification.; to: PMID:18697825 (Li et al., 2008) suggested that the previously reported association with polymorphisms in the CLEC4M gene may be due to population stratification.
Viral resistance v0.59 CLEC4M Rebecca Foulger changed review comment from: In contrast to Chan et al., 2006 (PMID:16369534), Tang et al. (2007, PMID:17534354) found no support for an association between CLEC4M homozygosity and protection against SARS. Zhi et al. (2007, PMID:17534355]) also found that the protective effect of CLEC4M homozygosity could not be replicated. The authors from the original study (PMID:16369534) suggested that controls were not matched in these subsequent studies.; to: In contrast to Chan et al., 2006 (PMID:16369534), Tang et al. (2007, PMID:17534354) found no support for an association between CLEC4M homozygosity and protection against SARS. Zhi et al. (2007, PMID:17534355) also found that the protective effect of CLEC4M homozygosity could not be replicated. The authors from the original study (PMID:16369534) suggested that controls were not matched in these subsequent studies.
Viral resistance v0.59 CLEC4M Rebecca Foulger Classified gene: CLEC4M as Red List (low evidence)
Viral resistance v0.59 CLEC4M Rebecca Foulger Added comment: Comment on list classification: Although a 2006 study finds an association between tandem repeats within CLEC4M , and protection against SARS viral infection, subsequent studies do not support this association. Therefore rated as Red awaiting further evidence.
Viral resistance v0.59 CLEC4M Rebecca Foulger Gene: clec4m has been classified as Red List (Low Evidence).
Viral resistance v0.58 CLEC4M Rebecca Foulger Publications for gene: CLEC4M were set to 16369534
Viral resistance v0.57 CLEC4M Rebecca Foulger commented on gene: CLEC4M: PMID:18697825 (Li et al., 2008) suggested that the previously reported association with polymorphisms in the CLEC4M neck region may be due to population stratification.
Viral resistance v0.57 CLEC4M Rebecca Foulger commented on gene: CLEC4M: In contrast to Chan et al., 2006 (PMID:16369534), Tang et al. (2007, PMID:17534354) found no support for an association between CLEC4M homozygosity and protection against SARS. Zhi et al. (2007, PMID:17534355]) also found that the protective effect of CLEC4M homozygosity could not be replicated. The authors from the original study (PMID:16369534) suggested that controls were not matched in these subsequent studies.
Viral resistance v0.57 CLEC4M Rebecca Foulger gene: CLEC4M was added
gene: CLEC4M was added to Viral resistance. Sources: Other
Mode of inheritance for gene: CLEC4M was set to Unknown
Publications for gene: CLEC4M were set to 16369534
Phenotypes for gene: CLEC4M were set to SARS infection, protection against, 605872
Added comment: Added to panel based on OMIM search. CLEC4M has considerable polymorphism in the tandem repeat domain of exon 4 (3 to 9 repeats of a 69-basepair segment, with 7 repeats being predominant in the general population). Chan et al. (2006, PMID:16369534) performed a genetic risk association study and found that individuals homozygous for CLEC4M tandem repeats are less susceptible to SARS infection. CLEC4M was expressed in both non-SARS and SARS-CoV-infected lung. Compared with cells heterozygous for CLEC4M, cells homozygous for CLEC4M showed higher binding capacity for SARS-CoV, higher proteasome-dependent viral degradation, and a lower capacity for trans infection. Thus, homozygosity for CLEC4M plays a protective role during SARS infection.
Sources: Other