Viral resistance
Gene: CXCR1Comment on list classification: PMID: 17360650 found a CXCR1 haplotype made up of 2 SNPs (rs16858811) that caused M31R change in the N-terminal extracellular domain, and rs1658808 caused R335C in the C-terminal intracellular domain. The frequency of this haplotype was significantly lower in 84 French HIV-1-infected patients who progressed rapidly to AIDS compared with 253 French HIV-1-infected patients who progressed slowly to AIDS. The authors concluded that the CXCR1 haplotype protects against rapid progression of HIV-1 infected patients to AIDS.
PMID: 25121556 showed the mechanism of how the CXCR1 haplotype affects AIDS progression.Created: 4 May 2020, 1:24 p.m. | Last Modified: 4 May 2020, 1:24 p.m.
Panel Version: 0.32
Gene: cxcr1 has been classified as Green List (High Evidence).
Mode of inheritance for gene: CXCR1 was changed from to Unknown
Gene: cxcr1 has been classified as Amber List (Moderate Evidence).
Publications for gene: CXCR1 were set to 17360650
gene: CXCR1 was added gene: CXCR1 was added to Viral resistance. Sources: OMIM Mode of inheritance for gene: CXCR1 was set to Publications for gene: CXCR1 were set to 17360650 Phenotypes for gene: CXCR1 were set to {AIDS, slow progression to} 609423