Viral resistance
Gene: FUT2
Comment on list classification: There are >3 published papers describing homozygous variant (G428A), which inactivates the FUT2 protein causing it to not make H type-1 ligand that is required for virus binding, conferring virus resistance. This variant is present in ~20% of European population.
Therefore there is enough evidence to promote this gene to Green status.Created: 28 Apr 2020, 10:33 a.m. | Last Modified: 28 Apr 2020, 10:33 a.m.
Panel Version: 0.16
This gene has been added from https://www.covidhge.com/ and will require further curation, therefore it is currently rated as Amber.
Sources: Expert list, LiteratureCreated: 20 Apr 2020, 12:12 p.m.
Mode of inheritance
Unknown
Gene: fut2 has been classified as Green List (High Evidence).
Publications for gene: FUT2 were set to
Mode of inheritance for gene: FUT2 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal
Phenotypes for gene: FUT2 were changed from to {Norwalk virus infection, resistance to}
Gene: fut2 has been classified as Amber List (Moderate Evidence).
gene: FUT2 was added gene: FUT2 was added to Viral resistance. Sources: Expert list,Literature Mode of inheritance for gene: FUT2 was set to Unknown Review for gene: FUT2 was set to AMBER