Viral resistance
Gene: CCR5
Comment on list classification: CCR5 is the primary HIV co-receptor (PMID: 29932942). PMID: 8751444, 8756719 and 8791590 found that individuals with homozygous 32 bp del in CCR5 (caused frameshift and premature termination) were protected from HIV-1 infection. This variant has AF of ~1% in Caucasian populations but absent in western and central Africa and Japan. Those with a heterozygous variant have a moderate but consistent decrease in the rate of disease progression. PMID: 19213682 describes a case ("Berline patient") where an HIV-1 infected patient received a hematopoietic stem cell transplantation where the donor was homozygous for CCR5 32del. The patient has remained HIV free for >10 years.
It has also been suggested that CCR5 32del confers resistance to hepatitis C virus (HVC) infections; however, more data is still needed for this (PMID: 29415549).
Therefore, there is sufficient evidence for this gene to be rated Green on this panel.Created: 28 Apr 2020, 2:58 p.m. | Last Modified: 28 Apr 2020, 2:58 p.m.
Panel Version: 0.22
Comment on mode of inheritance: In reference to HIV resistance, Biallelic mutations confer stronger resistance against infection than Monoallelic mutations.Created: 28 Apr 2020, 2:36 p.m. | Last Modified: 28 Apr 2020, 2:36 p.m.
Panel Version: 0.19
This gene has been added from https://www.covidhge.com/ and will require further curation, therefore it is currently rated as Amber.
Sources: Literature, Expert listCreated: 20 Apr 2020, 12:11 p.m.
Mode of inheritance
Unknown
Gene: ccr5 has been classified as Green List (High Evidence).
Publications for gene: CCR5 were set to
Mode of inheritance for gene: CCR5 was changed from Unknown to BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal
Phenotypes for gene: CCR5 were changed from to {Hepatitis C virus, resistance to}, 609532; {HIV infection, susceptibility/resistance to}
Gene: ccr5 has been classified as Amber List (Moderate Evidence).
gene: CCR5 was added gene: CCR5 was added to Viral resistance. Sources: Literature,Expert list Mode of inheritance for gene: CCR5 was set to Unknown Review for gene: CCR5 was set to AMBER