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| Viral resistance v0.44 | CXCR1 | Ivone Leong Classified gene: CXCR1 as Green List (high evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Viral resistance v0.44 | CXCR1 | Ivone Leong Gene: cxcr1 has been classified as Green List (High Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Viral resistance v0.43 | CXCR1 | Ivone Leong Mode of inheritance for gene: CXCR1 was changed from to Unknown | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Viral resistance v0.32 | CXCR1 | Ivone Leong Classified gene: CXCR1 as Amber List (moderate evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Viral resistance v0.32 | CXCR1 |
Ivone Leong Added comment: Comment on list classification: PMID: 17360650 found a CXCR1 haplotype made up of 2 SNPs (rs16858811) that caused M31R change in the N-terminal extracellular domain, and rs1658808 caused R335C in the C-terminal intracellular domain. The frequency of this haplotype was significantly lower in 84 French HIV-1-infected patients who progressed rapidly to AIDS compared with 253 French HIV-1-infected patients who progressed slowly to AIDS. The authors concluded that the CXCR1 haplotype protects against rapid progression of HIV-1 infected patients to AIDS. PMID: 25121556 showed the mechanism of how the CXCR1 haplotype affects AIDS progression. |
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| Viral resistance v0.32 | CXCR1 | Ivone Leong Gene: cxcr1 has been classified as Amber List (Moderate Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Viral resistance v0.31 | CXCR1 | Ivone Leong Publications for gene: CXCR1 were set to 17360650 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Viral resistance v0.20 | CXCR1 |
Sarah Leigh gene: CXCR1 was added gene: CXCR1 was added to Viral resistance. Sources: OMIM Mode of inheritance for gene: CXCR1 was set to Publications for gene: CXCR1 were set to 17360650 Phenotypes for gene: CXCR1 were set to {AIDS, slow progression to} 609423 |
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