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STRs in panel
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COVID-19 research

Gene: CCL5

Green List (high evidence)

CCL5 (C-C motif chemokine ligand 5)
EnsemblGeneIds (GRCh38): ENSG00000271503
EnsemblGeneIds (GRCh37): ENSG00000161570
OMIM: 187011, Gene2Phenotype
CCL5 is in 2 panels

4 reviews

Sarah Leigh (Genomics England Curator)

Comment on list classification: Based on expert review by Sophie Hambleton (Newcastle University)
Created: 11 May 2020, 4:04 p.m. | Last Modified: 11 May 2020, 4:04 p.m.
Panel Version: 0.206
Preprint https://doi.org/10.1101/2020.05.02.20084673 reports 10 terminally-ill, critical COVID-19 patients with profound elevation of plasma IL-6 and CCL5 (RANTES), decreased CD8+ T cell levels, and SARS-CoV-2 plasma viremia. Treatment with CCR5 blocking antibody leronlimab, results in complete CCR5 receptor occupancy on macrophage and T cells, rapid reduction of plasma IL-6, restoration of the CD4/CD8 ratio, and a significant decrease in SARS-CoV-2 plasma viremia. From single-cell RNA-sequencing, this effect appears to be a result of reduced transcriptomic myeloid cell clusters expressing IL-6 and interferon-related genes.
Created: 11 May 2020, 3:23 p.m. | Last Modified: 11 May 2020, 3:23 p.m.
Panel Version: 0.205

Publications

  • https://doi.org/10.1101/2020.05.02.20084673

Sophie Hambleton (Newcastle University)

Green List (high evidence)

Makes sense to evaluate influence of variants on susceptibility to severe COVID
Created: 7 May 2020, 4:12 p.m. | Last Modified: 7 May 2020, 4:12 p.m.
Panel Version: 0.204

Rebecca Foulger (Genomics England curator)

Comment on list classification: Updated rating from Red to Amber: Some evidence that CCL5 (aka RANTES) polymorphisms may be associated with viral infections, including SARS.
Created: 14 Apr 2020, 2:37 p.m. | Last Modified: 14 Apr 2020, 2:37 p.m.
Panel Version: 0.91
PMID:30175654 (El-Bendary et al., 2019) report rs3817655 polymorphism in CCL5 may be associated with spontaneous clearance of Hepatitis C virus (HCV).
Created: 14 Apr 2020, 2:36 p.m. | Last Modified: 14 Apr 2020, 2:36 p.m.
Panel Version: 0.89
PMID:31874580 (Sheng et al. 2019) study suggests that the CCL5 rs2107538 polymorphism was correlated with TB (infectious disease caused by Mycobacterium tuberculosis) susceptibility in Caucasians. The rs2107538 polymorphism is suggested to affect CCL5 expression.
Created: 14 Apr 2020, 2:36 p.m. | Last Modified: 14 Apr 2020, 2:36 p.m.
Panel Version: 0.89
PMID:22576913 (Al-Qahtani et al 2012) show -403G>A and -28C>G SNPs in the CCL5 (aka RANTES) gene are associated with Hepatitis B virus infection in a Saudi population.
Created: 14 Apr 2020, 2:22 p.m. | Last Modified: 14 Apr 2020, 2:22 p.m.
Panel Version: 0.88

Ellen McDonagh (Genomics England Curator)

PMID: 17540042 case-control study reporting an associated with a polymorphism in the CCL5 gene and admission to intensive care units or death due to SARS infection.
Sources: Literature
Created: 30 Mar 2020, 4:15 p.m.

Mode of inheritance
BOTH monoallelic and biallelic, autosomal or pseudoautosomal

Phenotypes
Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Infection; Susceptibility to SARS-CoV

Publications

Details

Mode of Inheritance
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Sources
  • Expert Review Green
Phenotypes
  • Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Infection
  • Susceptibility to SARS-CoV
OMIM
187011
Clinvar variants
Variants in CCL5
Penetrance
None
Publications
Panels with this gene

History Filter Activity

11 May 2020, Gel status: 3

Entity classified by Genomics England curator

Sarah Leigh (Genomics England Curator)

Gene: ccl5 has been classified as Green List (High Evidence).

14 Apr 2020, Gel status: 2

Entity classified by Genomics England curator

Rebecca Foulger (Genomics England curator)

Gene: ccl5 has been classified as Amber List (Moderate Evidence).

14 Apr 2020, Gel status: 1

Set publications

Rebecca Foulger (Genomics England curator)

Publications for gene: CCL5 were set to 17540042; 22576913

14 Apr 2020, Gel status: 1

Set publications

Rebecca Foulger (Genomics England curator)

Publications for gene: CCL5 were set to 17540042

30 Mar 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Ellen McDonagh (Genomics England Curator)

gene: CCL5 was added gene: CCL5 was added to Viral susceptibility. Sources: Literature Mode of inheritance for gene: CCL5 was set to BOTH monoallelic and biallelic, autosomal or pseudoautosomal Publications for gene: CCL5 were set to 17540042 Phenotypes for gene: CCL5 were set to Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Infection; Susceptibility to SARS-CoV