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COVID-19 research


Amber List (moderate evidence)

SERINC5 (serine incorporator 5)
EnsemblGeneIds (GRCh38): ENSG00000164300
EnsemblGeneIds (GRCh37): ENSG00000164300
OMIM: 614551, Gene2Phenotype
SERINC5 is in 1 panel

1 review

Catherine Snow (Genomics England)

I don't know

Curation by Illumina clinical curators contributing to Covid-19 effort. Curation on all OMIM genes which hit the term "virus".

Currently no gene disease association for SERINC5.

Screening human cell lines and using CRISPR-Cas9 analysis, Rosa et al. (2015) found that SERINC5, and to a lesser extent SERINC3 inhibited infectivity of human immunodeficiency virus (HIV)-1 and murine leukemia retrovirus (MLV)
Sudderuddin et al (2020) found that SERINC5 on the cell surface is down regulated upon HIV infection
Sources: Literature
Created: 22 May 2020, 3:09 p.m. | Last Modified: 22 May 2020, 3:09 p.m.
Panel Version: 0.311

Mode of inheritance



Mode of Inheritance
  • Expert Review Amber
  • Literature
Clinvar variants
Variants in SERINC5
Panels with this gene

History Filter Activity

22 May 2020, Gel status: 2

Entity classified by Genomics England curator

Catherine Snow (Genomics England)

Gene: serinc5 has been classified as Amber List (Moderate Evidence).

22 May 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications

Catherine Snow (Genomics England)

gene: SERINC5 was added gene: SERINC5 was added to COVID-19 research. Sources: Literature Mode of inheritance for gene: SERINC5 was set to Unknown Publications for gene: SERINC5 were set to 26416734; 31918727 Review for gene: SERINC5 was set to AMBER