COVID-19 research
Gene: FANCB
Mode of inheritance
X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)
Phenotypes
Fanconi anaemia; bone marrow failure
IUIS: categorised under bone marrow failure with immune deficiency - Fanconi Anemia section. Inheritance XLR. T cells: normal to low. B cells: normal to low. Other affected cells: HSC. Associated features: Normal to low NK, CNS, skeletal, skin, cardiac, GI, urogenital anomalies, increased chromosomal breakage.Created: 15 Apr 2020, 12:09 p.m. | Last Modified: 15 Apr 2020, 12:09 p.m.
Panel Version: 0.103
Mode of inheritance
X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)
Phenotypes
Fanconi anemia, complementation group B, 300514
Publications
gene: FANCB was added gene: FANCB was added to Viral susceptibility. Sources: Expert Review Green,IUIS Classification December 2019 Mode of inheritance for gene: FANCB was set to X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males) Publications for gene: FANCB were set to 32086639; 32048120 Phenotypes for gene: FANCB were set to Fanconi anemia, complementation group B, 300514