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COVID-19 research

Gene: CD244

Green List (high evidence)

CD244 (CD244 molecule)
EnsemblGeneIds (GRCh38): ENSG00000122223
EnsemblGeneIds (GRCh37): ENSG00000122223
OMIM: 605554, Gene2Phenotype
CD244 is in 1 panel

2 reviews

Ivone Leong (Genomics England Curator)

Green List (high evidence)

PMID: 23248626. CD244 helps regulate natural killer (NK) cell anti-viral activity and virus-specific CD8 T-cells and is involved in virus infections.

PMID: 21064032. In chronic HBV infection, Virus-specific CD8+ T-cells expressed higher levels of CD244 in chronic HBV infection. CD244 was expressed at high levels in EBV infection but low for influenza. CD244 may be potential target for immunotherapy in chronic viral infections.

PMID: 28396665 CD244 is upregulated in NK cells in HIV-infected treatment-naive patients, which is strongly correlated with HIV disease progression.
Created: 28 May 2020, 1:41 p.m. | Last Modified: 28 May 2020, 1:41 p.m.
Panel Version: 0.338

Rebecca Foulger (Genomics England curator)

Identified through an OMIM search for potential viral susceptibility genes, and subsequently triaged/reviewed by Illumina curation team.
Created: 28 May 2020, 12:36 p.m. | Last Modified: 28 May 2020, 12:36 p.m.
Panel Version: 0.336

Details

Mode of Inheritance
Unknown
Sources
OMIM
605554
Clinvar variants
Variants in CD244
Penetrance
None
Publications
Panels with this gene

History Filter Activity

28 May 2020, Gel status: 3

Set publications

Ivone Leong (Genomics England Curator)

Publications for gene: CD244 were set to

28 May 2020, Gel status: 3

Created, Added New Source, Set mode of inheritance

Rebecca Foulger (Genomics England curator)

gene: CD244 was added gene: CD244 was added to COVID-19 research. Sources: Expert list,OMIM,Expert Review Green Mode of inheritance for gene: CD244 was set to Unknown