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COVID-19 research

Gene: TBX21

Amber List (moderate evidence)

TBX21 (T-box 21)
EnsemblGeneIds (GRCh38): ENSG00000073861
EnsemblGeneIds (GRCh37): ENSG00000073861
OMIM: 604895, Gene2Phenotype
TBX21 is in 1 panel

1 review

Ivone Leong (Genomics England Curator)

I don't know

TBX21 is a Th1-specific T-box transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (PMID: 15806396).

PMID: 17378728 found that variations at allele -1499 and haplotype D (--/AC) in the TBX21 promoter region contribute to susceptibility to HBV infection in the Chinese population.

PMID: 19473434 found that T-1993C polymorphism in the TBX21 promoter influences susceptibility to persistent HBV infection.

PMID: 29399747 found that rs4794067 (T-1993C) is significantly correlated with increased risk of HCV chronic infection (dominant model: OR = 5.690, 95% CI = 2.024-16.000) and susceptibility (dominant model: OR = 5.658, 95% CI = 2.514-12.735).
Sources: Expert list
Created: 26 May 2020, 9:32 a.m.

Mode of inheritance
Unknown

Phenotypes
{Asthma, aspirin-induced, susceptibility to}, 208550; susceptibility to chronic HBV and HCV infection

Publications

Details

Mode of Inheritance
Unknown
Sources
  • Expert Review Amber
  • Expert list
Phenotypes
  • {Asthma, aspirin-induced, susceptibility to}, 208550
  • susceptibility to chronic HBV and HCV infection
OMIM
604895
Clinvar variants
Variants in TBX21
Penetrance
None
Publications
Panels with this gene

History Filter Activity

26 May 2020, Gel status: 2

Entity classified by Genomics England curator

Ivone Leong (Genomics England Curator)

Gene: tbx21 has been classified as Amber List (Moderate Evidence).

26 May 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Ivone Leong (Genomics England Curator)

gene: TBX21 was added gene: TBX21 was added to COVID-19 research. Sources: Expert list Mode of inheritance for gene: TBX21 was set to Unknown Publications for gene: TBX21 were set to 15806396; 17378728; 19473434; 29399747 Phenotypes for gene: TBX21 were set to {Asthma, aspirin-induced, susceptibility to}, 208550; susceptibility to chronic HBV and HCV infection Review for gene: TBX21 was set to AMBER