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COVID-19 research

Gene: HTR2A

Red List (low evidence)

HTR2A (5-hydroxytryptamine receptor 2A)
EnsemblGeneIds (GRCh38): ENSG00000102468
EnsemblGeneIds (GRCh37): ENSG00000102468
OMIM: 182135, Gene2Phenotype
HTR2A is in 1 panel

1 review

Sarah Leigh (Genomics England Curator)

Red List (low evidence)

HTR2A gene product - serotonergic receptor (5HT(2A)R) can act as a cell receptor for human polyomavirus JCV (JVC) on on human glial cells. 5HT(2A)R antagonists inhibit JVC infection and monoclonal antibodies to 5HT(2A)R blocked the viral infection (PMID 15550673).
Created: 4 May 2020, 3:17 p.m. | Last Modified: 4 May 2020, 3:17 p.m.
Panel Version: 0.176



  • OMIM
Clinvar variants
Variants in HTR2A
Panels with this gene

History Filter Activity

21 Apr 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance

Sarah Leigh (Genomics England Curator)

gene: HTR2A was added gene: HTR2A was added to Viral susceptibility. Sources: OMIM Mode of inheritance for gene: HTR2A was set to