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COVID-19 research

Gene: CD14

Green List (high evidence)

CD14 (CD14 molecule)
EnsemblGeneIds (GRCh38): ENSG00000170458
EnsemblGeneIds (GRCh37): ENSG00000170458
OMIM: 158120, Gene2Phenotype
CD14 is in 1 panel

4 reviews

Catherine Snow (Genomics England)

Comment on list classification: Upgrade to Green based on expert review from Sophie Hambleton
Created: 12 May 2020, 8:42 a.m. | Last Modified: 12 May 2020, 8:42 a.m.
Panel Version: 0.209

Sophie Hambleton (Newcastle University)

Green List (high evidence)

Makes sense to evaluate influence of variants on susceptibility to severe COVID
Created: 7 May 2020, 4:13 p.m. | Last Modified: 7 May 2020, 4:13 p.m.
Panel Version: 0.204

Rebecca Foulger (Genomics England curator)

Comment on list classification: Updated rating from Red to Amber: at least 2 publications supporting a link between CD14 polymorphism and viral infection (SARs and RSV).
Created: 14 Apr 2020, 3:04 p.m. | Last Modified: 14 Apr 2020, 3:04 p.m.
Panel Version: 0.98
PMID:25572736 (Goutaki et al., 2014) find a positive association between the development of bronchiolitis (clinical manifestation of respiratory syncytial virus/RSV infection) and the CD14 C-159T polymorphism.
Created: 14 Apr 2020, 3:02 p.m. | Last Modified: 14 Apr 2020, 3:02 p.m.
Panel Version: 0.96

Ellen McDonagh (Genomics England Curator)

PMID: case-control study reporting association with a risk genotype of a polymorphism in this gene and severe SARS-CoV infection.
Sources: Literature
Created: 30 Mar 2020, 4:14 p.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Phenotypes
Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Infection; Susceptibility to SARS-CoV

Publications

Details

Mode of Inheritance
Unknown
Sources
  • Expert Review Green
Phenotypes
  • Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Infection
  • Susceptibility to SARS-CoV
OMIM
158120
Clinvar variants
Variants in CD14
Penetrance
None
Publications
Panels with this gene

History Filter Activity

27 May 2020, Gel status: 3

Set mode of inheritance

Catherine Snow (Genomics England)

Mode of inheritance for gene: CD14 was changed from MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown to Unknown

12 May 2020, Gel status: 3

Entity classified by Genomics England curator

Catherine Snow (Genomics England)

Gene: cd14 has been classified as Green List (High Evidence).

14 Apr 2020, Gel status: 2

Entity classified by Genomics England curator

Rebecca Foulger (Genomics England curator)

Gene: cd14 has been classified as Amber List (Moderate Evidence).

14 Apr 2020, Gel status: 1

Set publications

Rebecca Foulger (Genomics England curator)

Publications for gene: CD14 were set to 17913858

30 Mar 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Ellen McDonagh (Genomics England Curator)

gene: CD14 was added gene: CD14 was added to Viral susceptibility. Sources: Literature Mode of inheritance for gene: CD14 was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown Publications for gene: CD14 were set to 17913858 Phenotypes for gene: CD14 were set to Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Infection; Susceptibility to SARS-CoV