COVID-19 research
Gene: CD14Comment on list classification: Upgrade to Green based on expert review from Sophie HambletonCreated: 12 May 2020, 8:42 a.m. | Last Modified: 12 May 2020, 8:42 a.m.
Panel Version: 0.209
Makes sense to evaluate influence of variants on susceptibility to severe COVIDCreated: 7 May 2020, 4:13 p.m. | Last Modified: 7 May 2020, 4:13 p.m.
Panel Version: 0.204
Comment on list classification: Updated rating from Red to Amber: at least 2 publications supporting a link between CD14 polymorphism and viral infection (SARs and RSV).Created: 14 Apr 2020, 3:04 p.m. | Last Modified: 14 Apr 2020, 3:04 p.m.
Panel Version: 0.98
PMID:25572736 (Goutaki et al., 2014) find a positive association between the development of bronchiolitis (clinical manifestation of respiratory syncytial virus/RSV infection) and the CD14 C-159T polymorphism.Created: 14 Apr 2020, 3:02 p.m. | Last Modified: 14 Apr 2020, 3:02 p.m.
Panel Version: 0.96
PMID: case-control study reporting association with a risk genotype of a polymorphism in this gene and severe SARS-CoV infection.
Sources: LiteratureCreated: 30 Mar 2020, 4:14 p.m.
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Phenotypes
Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Infection; Susceptibility to SARS-CoV
Publications
Mode of inheritance for gene: CD14 was changed from MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown to Unknown
Gene: cd14 has been classified as Green List (High Evidence).
Gene: cd14 has been classified as Amber List (Moderate Evidence).
Publications for gene: CD14 were set to 17913858
gene: CD14 was added gene: CD14 was added to Viral susceptibility. Sources: Literature Mode of inheritance for gene: CD14 was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown Publications for gene: CD14 were set to 17913858 Phenotypes for gene: CD14 were set to Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Infection; Susceptibility to SARS-CoV