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COVID-19 research

Gene: TNFSF10

Amber List (moderate evidence)

TNFSF10 (TNF superfamily member 10)
EnsemblGeneIds (GRCh38): ENSG00000121858
EnsemblGeneIds (GRCh37): ENSG00000121858
OMIM: 603598, Gene2Phenotype
TNFSF10 is in 1 panel

1 review

Rebecca Foulger (Genomics England curator)

Comment on list classification: Kept the Amber rating initially suggested by Illumina curation team: plays a role in viral surveillance, and virus can modulate TNFSF10 (TRAIL) signaling. Many studies look at expression levels following infection. No direct susceptibility studies, so Amber appropriate.
Created: 28 May 2020, 8:01 p.m. | Last Modified: 28 May 2020, 8:01 p.m.
Panel Version: 0.371
Summary of literature: TNFSF10/TRAIL is a death ligand that contributes to immune surveillance against virus-infected cells via the death receptor DR5. TNFSF10 binding induces the caspase cascade to kill the virus-infected cell. Many viruses evade antiviral immunity by modulating TNFSF10 receptor signaling.
Created: 28 May 2020, 7:57 p.m. | Last Modified: 28 May 2020, 7:58 p.m.
Panel Version: 0.369
Identified through an OMIM search for potential viral susceptibility genes, and subsequently triaged/reviewed by Illumina curation team.
Created: 28 May 2020, 12:36 p.m. | Last Modified: 28 May 2020, 12:36 p.m.
Panel Version: 0.336

Details

Mode of Inheritance
Unknown
Sources
OMIM
603598
Clinvar variants
Variants in TNFSF10
Penetrance
None
Publications
Panels with this gene

History Filter Activity

28 May 2020, Gel status: 2

Entity classified by Genomics England curator

Rebecca Foulger (Genomics England curator)

Gene: tnfsf10 has been classified as Amber List (Moderate Evidence).

28 May 2020, Gel status: 2

Set publications

Rebecca Foulger (Genomics England curator)

Publications for gene: TNFSF10 were set to 18802095; 14702109; 31725732; 27740879; 17913827; 15110181

28 May 2020, Gel status: 2

Set publications

Rebecca Foulger (Genomics England curator)

Publications for gene: TNFSF10 were set to 18802095; 14702109

28 May 2020, Gel status: 2

Set publications

Rebecca Foulger (Genomics England curator)

Publications for gene: TNFSF10 were set to

28 May 2020, Gel status: 2

Created, Added New Source, Set mode of inheritance

Rebecca Foulger (Genomics England curator)

gene: TNFSF10 was added gene: TNFSF10 was added to COVID-19 research. Sources: Expert list,OMIM,Expert Review Amber Mode of inheritance for gene: TNFSF10 was set to Unknown