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COVID-19 research

Gene: SLFN12

Red List (low evidence)

SLFN12 (schlafen family member 12)
EnsemblGeneIds (GRCh38): ENSG00000172123
EnsemblGeneIds (GRCh37): ENSG00000172123
OMIM: 614955, Gene2Phenotype
SLFN12 is in 1 panel

1 review

Ivone Leong (Genomics England Curator)

Red List (low evidence)

Mouse model-Immune system. Mice homozygous for the Slfn2 elektra mutation exhibited enhanced susceptibility to bacterial and viral infections and diminished numbers of T cells and inflammatory monocytes that failed to proliferate after infection and died via the intrinsic apoptotic pathway in response to diverse proliferative stimuli. Slfn2 homologous to SFLN12 and SLFN12L
Sources: Expert list
Created: 26 May 2020, 7:56 a.m.

Mode of inheritance


Mode of Inheritance
  • Expert list
Clinvar variants
Variants in SLFN12
Panels with this gene

History Filter Activity

26 May 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance

Ivone Leong (Genomics England Curator)

gene: SLFN12 was added gene: SLFN12 was added to COVID-19 research. Sources: Expert list Mode of inheritance for gene: SLFN12 was set to Unknown Review for gene: SLFN12 was set to RED