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COVID-19 research

Gene: DSG2

Amber List (moderate evidence)

DSG2 (desmoglein 2)
EnsemblGeneIds (GRCh38): ENSG00000046604
EnsemblGeneIds (GRCh37): ENSG00000046604
OMIM: 125671, Gene2Phenotype
DSG2 is in 10 panels

2 reviews

Catherine Snow (Genomics England)

Wang et al (PMID:21151137) identified desmoglein-2 (DSG-2) as the primary high-affinity receptor used by adenoviruses. PMID: 30862836 adds support to this as CryoEM structure of adenovirus type 3 fibre with desmoglein 2 shows an unusual mode of receptor engagement.
Created: 28 May 2020, 3:14 p.m. | Last Modified: 28 May 2020, 3:14 p.m.
Panel Version: 0.347


Rebecca Foulger (Genomics England curator)

Identified through an OMIM search for potential viral susceptibility genes, and subsequently triaged/reviewed by Illumina curation team.
Created: 28 May 2020, 12:36 p.m. | Last Modified: 28 May 2020, 12:36 p.m.
Panel Version: 0.336

History Filter Activity

28 May 2020, Gel status: 2

Set publications

Catherine Snow (Genomics England)

Publications for gene: DSG2 were set to

28 May 2020, Gel status: 2

Created, Added New Source, Set mode of inheritance

Rebecca Foulger (Genomics England curator)

gene: DSG2 was added gene: DSG2 was added to COVID-19 research. Sources: Expert list,OMIM,Expert Review Amber Mode of inheritance for gene: DSG2 was set to Unknown